… program which results in the appearance of multiple phenotypic forms. In fact, the final result
… the concepts of phenotypic and morphologic variations in C. neoformans with the purpose …

… We have identified a gene (HVA1) whose absence is associated with a hypervirulent phenotype
… Fungal burden experiments in macrophages recapitulate the hypervirulent phenotype in …

… number of known lineages with their own distinct phenotypes. All of these variants were derived
from … This hyper-virulent phenotype of the H99S strain was confirmed in a rabbit model of …

… We screened the heteroresistant phenotype by plating cells onto YPD agar supplemented
… Not all strains heteroresistant at high levels of FLC were hypervirulent, but all highly virulent …

… The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated
… , we found that the lethality of each strain ranged from hypervirulent (H99 and WM629), to …

… : the strains were naturally occurring hypervirulent pkr1 (PKA … Next, we tested whether the
strains exhibited phenotypes of pkr1 … The enhanced capsule phenotype of isolate ICPMR …

… Isolates from the Cryptococcus neoformans–Cryptococcus gattii complex are the etiological
agents of … Our findings showed that the hypervirulent isolate CG02 had increased rates of …

… The best characterized fungal capsule belongs to Cryptococcus neoformans. The capsule
of this microorganism has been extensively studied because it is the main virulence factor of …

Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in
immunocompromised individuals and latently infects many healthy individuals. C. neoformans, …

… Mutations altering the PKA regulatory subunit gene PKR1 constitutively activate the PKA
signaling cascade and result in increased capsule production and a hypervirulent phenotype in …