… CTH1 is transiently induced by Aft1 and Aft2 after iron deprivation and its mRNA levels are
unchanged in Atf1 gain-of-function mutants [115, 121, 129, 150]. Cth1 controls the mRNA …

… concentration and Fe deprivation. In conclusion, cryptococcal polysaccharide synthesis is …
The polysaccharide capsule is a major virulence factor for Cryptococcus neoformans [1, 2]. It …

… , cryptococcosis, is generally characterized by meningitis and is mainly caused by two closely
related species of encapsulated basidiomycetous yeasts (Cryptococcus neoformans and C…

… levels are induced by response to glucose deprivation [22]. … negatively regulates genes for
iron uptake and positively … also examined the influence of iron on OVA1 transcript levels and …

… to iron deprivation. Finally, we found a connection between Hap43 and the global corepressor
Tup1 in low-iron-… Cryptococcus neoformans Cir1 (44). These repressors function under …

The ability of the human fungal pathogen Cryptococcus neoformans to adapt to variable
copper (Cu) environments within the host is key for successful dissemination and colonization. …

… by iron deprivation, by haem and by a temperature shift from 30 to 37 C (Santos, 2003).
Furthermore, a Δhmx1 mutant was unable to grow under iron restriction caused by the iron …

… uptake of metals like iron. Studies have shown that copper deprivation is a strategy used by
the host against pathogenic fungi such as Cryptoccocus neoformans and Candida albicans …

… are conserved in C. carrionii and that iron deprivation induces both systems in this fungus.
Considering the low iron availability imposed by the nutritional immunity, those high-affinity …

… We found the C-terminus of Hap43 to be essential for the activation of iron uptake genes …
conclude that only C- and N-termini of Hap43 are crucial for its function under iron deprivation. …