… Cryptococcus neoformans. Fitness has been defined as the ability of an organism to propagate
and evolve within a given environment. Because the human host is an evolutionary dead-…

… The fungal pathogen Cryptococcus neoformans is well adapted to its host environment. It
has several defence mechanisms to evade oxidative and nitrosative agents released by …

… , the bioavailability of iron is low owing to … iron supply but to avoid iron toxicity, all organisms
evolved sophisticated mechanisms to balance acquisition, storage, and consumption of iron…

… Cryptococcus neoformans disseminates from the lung to the … of PHO signaling to cryptococcal
dissemination, we … transcription factor in phosphate-deprived cryptococci, accumulating in …

… .; White, R.; Kronstad, JW HapX positively and negatively regulates the transcriptional
response to iron deprivation in Cryptococcus neoformans. PLoS Pathog 2010, 6, e1001209, doi:…

… the yeast Cryptococcus neoformans (the agent of cryptococcosis, a … We have mainly focused
our discussion on iron sources and … to iron deprivation and they function in extracellular iron …

… capsulatum to nutritional deprivation. Finally, we demonstrate the importance of a strain … by
microarray analysis of C. neoformans [38] under reduced iron availability was similar to those …

… Cryptococcus neoformans is a facultative intracellular pathogen that can replicate and
disseminate in mammalian macrophages. In this study, we analyzed fungal proteins identified in …

… Other inducing conditions for capsule include iron deprivation, nutrient limitation, and the
presence of serum. The mechanisms by which these environmental signals are sensed and …

… Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus
neoformans by a mechanism independent of iron deprivation. J Clin Invest. 1997;100:1640–6. …