Connecting iron regulation and mitochondrial function in Cryptococcus neoformans
LC Horianopoulos, JW Kronstad - Current opinion in microbiology, 2019 - Elsevier
… such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms
to overcome host iron sequestration. Iron is of particular interest for C. neoformans because its …
to overcome host iron sequestration. Iron is of particular interest for C. neoformans because its …
Maintenance of mitochondrial morphology in Cryptococcus neoformans is critical for stress resistance and virulence
AL Chang, TL Doering - MBio, 2018 - Am Soc Microbiol
… To broadly assess mitochondrial function, we next measured succinate dehydrogenase
activity in our strain set by assaying the reduction of 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-…
activity in our strain set by assaying the reduction of 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-…
The zinc finger protein Mig1 regulates mitochondrial function and azole drug susceptibility in the pathogenic fungus Cryptococcus neoformans
… mitochondrial function and antifungal drug susceptibility in the fungus Cryptococcus
neoformans… HapX, and a role for Mig1 in mitochondrial functions, including respiration, tolerance …
neoformans… HapX, and a role for Mig1 in mitochondrial functions, including respiration, tolerance …
Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans
… phagocytosis results in modifications of critical cellular functions, including impaired
mitochondrial function, activation of caspase-1 and cellular stress pathways, and altered protein …
mitochondrial function, activation of caspase-1 and cellular stress pathways, and altered protein …
Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride
SS Ingavale, YC Chang, H Lee, CM McClelland… - PLoS …, 2008 - journals.plos.org
… In this study, we show that mitochondria play an important role for C. neoformans to survive
… genes related to mitochondrial functions have mitochondrial membrane permeability defect …
… genes related to mitochondrial functions have mitochondrial membrane permeability defect …
Cryptococcus neoformans Mitochondrial Superoxide Dismutase: an Essential Link between Antioxidant Function and High-Temperature Growth
SS Giles, I Batinic-Haberle, JR Perfect, GM Cox - Eukaryotic Cell, 2005 - Am Soc Microbiol
Manganese superoxide dismutase is an essential component of the mitochondrial
antioxidant defense system of most eukaryotes. In the present study, we used a reverse-genetics …
antioxidant defense system of most eukaryotes. In the present study, we used a reverse-genetics …
The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans
… study indicated that normal mitochondrial functions are impaired in the atm1 mutant of C. …
an important contribution to mitochondrial functions and defense against oxidative stress in C. …
an important contribution to mitochondrial functions and defense against oxidative stress in C. …
Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans
S Lev, C Li, D Desmarini, D Liuwantara, TC Sorrell… - Pathogens, 2020 - mdpi.com
… Cryptococcus neoformans is a human fungal pathogen that … To gain insight into cryptococcal
metabolism, we optimized a … with reduced mitochondrial function. Metabolic inflexibility in …
metabolism, we optimized a … with reduced mitochondrial function. Metabolic inflexibility in …
The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans
… novel observation that Vps45 also contributes to mitochondrial function in that a Vps45-Gfp …
as changes in mitochondrial membrane potential. Consistent with mitochondrial function, the …
as changes in mitochondrial membrane potential. Consistent with mitochondrial function, the …
The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans
… in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is
… We showed that these phenotypes were due in part to impaired mitochondrial function as a …
… We showed that these phenotypes were due in part to impaired mitochondrial function as a …
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