Connecting iron regulation and mitochondrial function in Cryptococcus neoformans

LC Horianopoulos, JW Kronstad - Current opinion in microbiology, 2019 - Elsevier
… such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms
to overcome host iron sequestration. Iron is of particular interest for C. neoformans because its …

Maintenance of mitochondrial morphology in Cryptococcus neoformans is critical for stress resistance and virulence

AL Chang, TL Doering - MBio, 2018 - Am Soc Microbiol
… To broadly assess mitochondrial function, we next measured succinate dehydrogenase
activity in our strain set by assaying the reduction of 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-…

The zinc finger protein Mig1 regulates mitochondrial function and azole drug susceptibility in the pathogenic fungus Cryptococcus neoformans

M Caza, G Hu, M Price, JR Perfect, JW Kronstad - Msphere, 2016 - Am Soc Microbiol
mitochondrial function and antifungal drug susceptibility in the fungus Cryptococcus
neoformans… HapX, and a role for Mig1 in mitochondrial functions, including respiration, tolerance …

Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans

C Coelho, ACO Souza, LS Derengowski… - The Journal of …, 2015 - journals.aai.org
… phagocytosis results in modifications of critical cellular functions, including impaired
mitochondrial function, activation of caspase-1 and cellular stress pathways, and altered protein …

Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride

SS Ingavale, YC Chang, H Lee, CM McClelland… - PLoS …, 2008 - journals.plos.org
… In this study, we show that mitochondria play an important role for C. neoformans to survive
… genes related to mitochondrial functions have mitochondrial membrane permeability defect …

Cryptococcus neoformans Mitochondrial Superoxide Dismutase: an Essential Link between Antioxidant Function and High-Temperature Growth

SS Giles, I Batinic-Haberle, JR Perfect, GM Cox - Eukaryotic Cell, 2005 - Am Soc Microbiol
Manganese superoxide dismutase is an essential component of the mitochondrial
antioxidant defense system of most eukaryotes. In the present study, we used a reverse-genetics …

The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans

E Do, S Park, MH Li, JM Wang, C Ding… - Medical …, 2018 - academic.oup.com
… study indicated that normal mitochondrial functions are impaired in the atm1 mutant of C. …
an important contribution to mitochondrial functions and defense against oxidative stress in C. …

Monitoring Glycolysis and Respiration Highlights Metabolic Inflexibility of Cryptococcus neoformans

S Lev, C Li, D Desmarini, D Liuwantara, TC Sorrell… - Pathogens, 2020 - mdpi.com
Cryptococcus neoformans is a human fungal pathogen that … To gain insight into cryptococcal
metabolism, we optimized a … with reduced mitochondrial function. Metabolic inflexibility in …

The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans

M Caza, G Hu, ED Nielson, M Cho, WH Jung… - PLoS …, 2018 - journals.plos.org
… novel observation that Vps45 also contributes to mitochondrial function in that a Vps45-Gfp …
as changes in mitochondrial membrane potential. Consistent with mitochondrial function, the …

The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans

E Do, M Park, G Hu, M Caza, JW Kronstad… - … and biophysical research …, 2016 - Elsevier
… in the human fungal pathogen, Cryptococcus neoformans, and found that LYS4 expression is
… We showed that these phenotypes were due in part to impaired mitochondrial function as a …