… neoformans in a mouse model. Our results further showed that cisplatin inhibited Prp8
intein splicing in vitro in a dose-dependent manner by direct binding to the Prp8 intein. Crystal …

… To examine the distribution of the CnePRP8 intein, we used PCR to test for the presence of
intein sequences in the PRP8 genes of multiple strains of Cryptococcus neoformans and the …

… has shown inhibition of the Cne Prp8 intein splicing with IC 50 values of … Prp8 intein splicing
activity. The antifungal efficacy of CMN was also tested in a mouse model of cryptococcosis…

… , are present in many human pathogens, including the emerging fungal threats
Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the causative agents of …

… for Cryptococcus neoformans, our aim was to investigate the presence of intein-like sequences
in C. … sequence database, we designed PCR primers to amplify the Cne PRP8 intein and …

… Here, we report the finding and characterization of Prp8 inteins from a wide range of … different
serotypes of Cryptococcus neoformans. We also demonstrate that Prp8 inteins from these …

… of PRP8 inteins in fungi other than species of Cryptococcus we searched … projects with the
predicted protein sequence of the C. … that the PRP8 genes of Cryptococcus neoformans and C. …

… Inteins in Prp8 are extremely pervasive and are found at 7 different sites in various species.
Here, we focus on the Prp8 intein from Cryptococcus neoformans (… the Hedgehog C terminus. …

… As Prp8 inteins are found in several important fungal pathogens and are absent in
mammals… the splicing of Prp8 intein from the yeast pathogen Cryptococcus neoformans (CnePrp8i) …

… inteins that can overcome these limitations. Here, we study the trans-splicing of CPE intein
obtained from the directed evolution of Cne PRP8… When the +1 residue of C-extein is changed …