… Cryptococcus neoformans CMN CMN acts as a Prp8 intein splicing inhibitor and specifically
inhibits the Prp8-Intein-containing fungi. CMN also reduces virulence factors, melanin …

… neoformans in a mouse model. Our results further showed that cisplatin inhibited Prp8
intein splicing in vitro in a dose-dependent manner by direct binding to the Prp8 intein. Crystal …

… RecA intein (Chan et al., 2016). Recent evidence suggests that cisplatin also targets an intein
within the essential splicesosomal Prp8 protein of the pathogen Cryptococcus neoformans …

… Recent evidence suggests that cisplatin also targets an intein within the essential splicesosomal
Prp8 protein of the pathogen Cryptococcus neoformans (21, 37). Thus, understanding …

… Cryptococcus neoformans and Cryptococcus gattii are encapsulated basidiomycetous …
Cryptococcus neoformans occurs world-wide, whereas C. gattii occurs predominantly in tropical …

… Here, we report an intein in important fungal pathogens including Aspergillus fumigatus, …
, and different serotypes of Cryptococcus neoformans. This intein is inside the extremely …

… inteins from pathogens, the RecA intein from M. tuberculosis (19) and the Prp8 intein from
Cryptococcus neoformans … tuberculosis RecA intein increases survival in response to cisplatin, …

… Phylogenetic analyses of PRP8 intein and URA5 sequences supported a topology where
AFLP7/VGIV clustered basal to the AFLP4/VGI and AFLP5/VGIII sister groups (23, 61), and …

… Cryptococcus neoformans, the agent of cryptococcosis, had been considered a … the
DNA sequences of the Cryptococcus neoformans PRP8 inteins (Butler & Poulter, 2005). …

… Phylogenetic trees were constructed based on individual and concatenated sequences
from representative pathogenic strains of the Cryptococcus neoformans/Cryptococcus gattii …