Impact of cytosine methylation on DNA binding specificities of human transcription factors

Y Yin, E Morgunova, A Jolma, E Kaasinen, B Sahu… - Science, 2017 - science.org
… effect of cytosine methylation on transcription factor binding, … transcription factors and
extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-…

Effects of cytosine methylation on transcription factor binding sites

YA Medvedeva, AM Khamis, IV Kulakovskiy… - BMC genomics, 2014 - Springer
Cytosine methylation may directly affect the affinity of transcription factors (TFs) towards their
… Non-systematic experimental evidence that DNA methylation can prevent binding of some …

The effects of cytosine methylation on general transcription factors

J Jin, T Lian, C Gu, K Yu, YQ Gao, XD Su - Scientific reports, 2016 - nature.com
… The only methylated cytosine in the possible base steps that we have not studied is the
latter cytosine in the CC context of ERE, which is very rare in the human genome (Supplementary …

Cytosine methylation does not affect binding of transcription factor Sp1.

MA Harrington, PA Jones… - Proceedings of the …, 1988 - National Acad Sciences
… the effect of cytosine methylation on the binding of the transcription factor Spl to its target …
The results therefore preclude a direct effect of cytosine methylation on Spl-DNA interactions…

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

F Watt, PL Molloy - Genes & development, 1988 - genesdev.cshlp.org
Cytosine methylation within CpG dinucleotides has been implicated in the regulation of …
in repression of transcription. We have examined whether methylation of CpG dinucleotides …

Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription

V Dostal, MEA Churchill - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
… In this study we examined the effects of cytosine methylation of CpG on TFAM DNA binding,
TFAM-dependent DNA compaction and transcription. Quantitative binding experiments …

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… While the chemical evidence of cytosine methylation was initially discovered in 1948 [16],
the first functional evidence that it could regulate physiological processes emerged in 1975 [17]…

[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors

JF Kribelbauer, XJ Lu, R Rohs, RS Mann… - Journal of molecular …, 2020 - Elsevier
… This review will primarily cover in vitro–based methods that quantify how TFs respond to
cytosine methylation and address to what extent the results of these assays have improved the …

Single-cytosine methylation at W-boxes repels binding of WRKY transcription factors through steric hindrance

M Charvin, T Halter, R Blanc-Mathieu… - Plant …, 2023 - academic.oup.com
… indicating that DNA methylation of a single cytosine, located in … 5-methyl group at this cytosine
likely alters binding of WRKY … mechanism by which cytosine methylation impedes binding …

Toward a base-resolution panorama of the in vivo impact of cytosine methylation on transcription factor binding

A Hernandez-Corchado, HS Najafabadi - Genome Biology, 2022 - Springer
… We introduce joint accessibility-methylation-sequence (JAMS) models, which connect the …
site, regional methylation level, DNA sequence, and base-resolution cytosine methylation. We …