… , a wave of global de novo methylation re-establishes the DNA methylation patterns that will
be maintained, in large part, in somatic tissues. Genome-wide demethylation also occurs in …

… at the genome level, which revealed that patterns of DNA methylation … DNA methylation for
genome regulation and the mechanisms that remodel the DNA methylome during mammalian …

… DNA methylation is a major force in mammalian … expression of exogenous DNA in plants
and animals that constrains … Understanding the biochemistry of DNA methylation dynamics is a …

… These include DNA methyltransferases (DNMTs), which catalyze the … demethylation. In this
chapter, we will discuss the mechanisms of DNA methylation and demethylation in mammals, …

… Modifications to histones and postreplicational modification of DNA are the focus of recent
extensive studies. In mammals and other vertebrates, DNA methylation occurs at the C 5 …

… In mammals, DNA methylation is reprogrammed in two significant phases: … DNA methylation
and demethylation. As such, much of the investigation of passive and active demethylation …

… In mammals, DNA methylation patterns are established during … DNA methylation marks
can be removed by either an active demethylation mechanism involving a family of DNA …

… in CpG dinucleotides plays an important role in mammalian … of DNA methylation across
mammalian genomes and progress in understanding the targeting and regulation of DNA …

… -dependent loss of DNA methylation is defined as passive demethylation. Despite genomewide
demethylation, imprinted genes are exempt from this process and remain methylated, as …

… , even though the genes were severely demethylated (18). ES cells retain a normal
phenotype in the absence of DNA methylation, but demethylation induces cell-autonomous …