… enhancers. We describe a chromatin state signature associated with active developmental
enhancers, … We also find that some developmental enhancers exhibit components of this …

… at early developmental stages in the mutant embryos account … Similarities include (1) an
enhancer of several hundred bp … activation of the Hoxd genes in early embryos, (3) restoration of …

… enhancer sequences and (b) utilize single-cell RNA sequencing to construct developmental
atlases of whole embryos… been implicated in early embryonic development. Indeed, …

… why loss of Ezh2 is early embryonic lethal and obligatory for the derivation of pluripotent …
Thus, Ezh2 is essential for early developmental events and in pluripotent ES cells, but not in …

… E11.5 and earlier embryos were staged according to somite number (Rugh, 1990). … litters
of embryos were analyzed for each developmental time point. hDRR/-2.5lacZ embryos were …

… Supporting the role of aCNEs as developmental enhancers, we observed that these regions
… Our results identify a substantial number of aCNEs that are established in the early embryo, …

… progress is a prerequisite for avoiding developmental defects or embryonic lethality, but the
… of dynamic epigenomes during mammalian early embryo development, taking advantage of …

… early embryo. Therefore, we examined maternal transcript localization in cleavage stage
Xenopus tropicalis embryos … to persist through later embryonic developmental stages (Figure 5D…

… developing embryos and documented a burst of enhancer activation during cleavage and
early … Our findings provide an atlas of developmental enhancers in a model sea urchin and …

… (F) α-HA and DAPI staining of HA-E(z) strain in early embryos at different developmental cycles
and at … Moreover, despite effective depletion of E(z) in early embryos, we could still detect …