Impaired active demethylation of the paternal genome in pronuclear‐stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection

Y Yoshizawa, M Kato, M Hirabayashi… - Molecular …, 2010 - Wiley Online Library
rat embryo production (IVF and ICSI) influenced the extent, but not the timing, of active
demethylation … Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol …

Demethylation in early embryonic development and memory

C Bernstein, H Bernstein - DNA Methylation Mechanism, 2019 - books.google.com
… At 24 h after training, 9.2% of the genes in the rat genomes of hippocampus neurons are …
embryonic development in evolution depended on preexisting DNA methylation/demethylation

Demethylation of CpG islands in embryonic cells

D Frank, I Keshet, M Shani, A Levine, A Razin, H Cedar - Nature, 1991 - nature.com
… and de novo methylation. To test whether DNA methylation inhibits gene expression in vivo,
… , b, Plasmid plns-1 containing the complete rat insulin-1 gene" was methylated in vitro with …

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes

M Wossidlo, J Arand, V Sebastiano, K Lepikhov… - The EMBO …, 2010 - embopress.org
DNA demethylation in cloned embryos at 2–8 h post‐activation (hpa). Ab's against 5mC show
a strong IF signal in activated SCNT embryos … Line1/ETn methylation in cloned embryos. (A…

Dynamic DNA methylation reprogramming: active demethylation and immediate remethylation in the male pronucleus of bovine zygotes

JS Park, YS Jeong, ST Shin, KK Lee… - … dynamics: an official …, 2007 - Wiley Online Library
DNA methylation patterns can be globally reset at certain developmental stages: first in
primordial germ cells and then in preimplantation embryos … actively demethylated (mouse and rat)…

[HTML][HTML] Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation

M Chu, F Yao, G Xi, J Yang, Z Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
DNA demethylation in IVF embryos, we next asked if the gene expression level of Tet family
members was inhibited in IVF preimplantation embryos. … inhibited in IVF embryos at the two- …

Active DNA demethylation of the vertebrate genomes by DNA methyltransferases: deaminase, dehydroxymethylase or demethylase?

KY Wang, CC Chen, CKJ Shen - Epigenomics, 2014 - Future Medicine
… that the DNA demethylation and dehydroxymethylation activities of the vertebrate DNMTs
play essential roles in multiple biological processes including early embryo development, …

Non-coding RNA directed DNA demethylation of Sphk1 CpG island

T Imamura, S Yamamoto, J Ohgane, N Hattori… - Biochemical and …, 2004 - Elsevier
… (D) In situ hybridization of Khps1 in cultured cells prepared from rat fetuses. An FITC-conjugated
anti-digoxigenin antibody (green) was reacted to visualize the probe complementary to …

DNA demethylation by DNA repair

M Gehring, W Reik, S Henikoff - Trends in Genetics, 2009 - cell.com
… Imprinting takes place in the endosperm, a tissue that supports embryo growth during seed
development and seedling germination. Active DNA demethylation has been implicated in …

[HTML][HTML] Dynamic changes in DNA modification states during late gestation male germ line development in the rat

CM Rose, S Van Den Driesche, RM Sharpe… - Epigenetics & …, 2014 - Springer
… Mouse studies indicate that DNA demethylation may be initiated at embryonic day (e) 8
and … of DNA methylation in the fetal rat testis for all currently recognised forms of cytosine …