… mC DNA methylation, identification and analysis of DNA methyltransferases and
demethyltransferases, and regulation of DNA methylation … changes can affect DNA methylation …

… A hallmark of cancer is the deregulation of the DNA methylation machinery and aberrant
DNA methylation patterns 1. In vertebrate genomes, a large fraction of the CG dinucleotide se…

… DNA methylation could be enzymatically reversed by demethylase activity [15] and that the
DNA methylation … targeting either DNA methylation or demethylation without affecting the …

… The first indications that DNA methylation patterns of particular genes may indeed be related
to their expression … DNA methylation in eukaryotes: kinetics of demethylation and de novo …

… has been studied extensively in the past 15 years, while the DNA demethylation … DNA
methylation/demethylation axis with special emphasis on the aspects of DNA demethylation…

… The silencing of transposons is also an important function of DNA methylation ( … accretion
of DNA methylation. This in turn reduces the requirement for active demethylation and could …

… Instead, active DNA methylation involves oxidation of the methylated base by ten-eleven
translocations (TETs), or deamination of the methylated or a nearby base by activation induced …

… demethylation has remained elusive. In this chapter we will review the evidence available on
DNA methylation … characterize enzymatic mechanismsofactive DNA demethylation. We will …

… As DNA methylation is reversible, DNA methylation inhibitors … block cancer growth with
DNA-demethylating drugs while avoiding … progress in using DNA methylation inhibitors in cancer …

… The responsible enzyme(s) remains unknown and the plant 5-methylcytosine DNA …
demethylation are known, fundamental processes that involve changes in DNA methylation, …