Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

PR Braun, S Han, B Hing, Y Nagahama… - Translational …, 2019 - nature.com
… as surrogates for DNA methylation in the brain. Blood, saliva, buccal, and live brain tissue
samples from 27 patients with medically intractable epilepsy undergoing brain resection were …

Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues

S Nishitani, M Isozaki, A Yao, Y Higashino… - Translational …, 2023 - nature.com
… For the first time, this study showed the genome-wide DNA methylation differences and
similarities between brain and blood tissues in the same individuals using Illumina 450 K array. …

[PDF][PDF] Differences in DNA methylation patterns between humans and chimpanzees

W Enard, A Fassbender, F Model, P Adorján, S Pääbo… - Current Biology, 2004 - cell.com
methylation in the brain, 14 are more methylated in humansmethylated in human brains
than in chimpanzee brains. … phenotypic differences, humans and their closest living relatives…

Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression

D Wang, M Szyf, C Benkelfat, N Provençal, G Turecki… - PloS one, 2012 - journals.plos.org
… processes such as DNA methylation and human behaviours. … in living human subjects
and their epigenetic profile, as brain … First, our current study compared DNA methylation with …

Aging effects on DNA methylation modules in human brain and blood tissue

S Horvath, Y Zhang, P Langfelder, RS Kahn… - Genome biology, 2012 - Springer
… [35] showed that MSCs from different tissues exhibit considerable differences in their
DNA methylation profiles, their growth pattern, immunophenotype and in vitro differentiation …

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

LF Wockner, EP Noble, BR Lawford… - Translational …, 2014 - nature.com
… , because it can be readily obtained from living patients. The epigenetic profile differs in the
differences in methylation status in brain tissue from schizophrenia patients compared with …

Neuronal activity modifies the DNA methylation landscape in the adult brain

JU Guo, DK Ma, H Mo, MP Ball, MH Jang… - Nature …, 2011 - nature.com
… Given the possibility of reactivation of DNA methylation–silenced retrotransposons in intergenic
regions 40 , we compared methylation patterns of 400 subclasses of repetitive elements …

DNA damage response and repair, DNA methylation, and cell death in human neurons and experimental animal neurons are different

LJ Martin, Q Chang - Journal of Neuropathology & Experimental …, 2018 - academic.oup.com
… (A) Phase contrast microscopy of live human neurons generated … among mouse, nonhuman
primate, and human brain cells (96, 98). … Our DNA methylation results support differences in …

Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain

F Lam, J Chu, JS Choi, C Cao… - Proceedings of the …, 2022 - National Acad Sciences
… , a model with stronger resemblance to human brains than … a DNA-methylation imaging
paradigm for living human brains. … brain hemispheres that revealed strong regional differences in …

DNA methylation age of human tissues and cell types

S Horvath - Genome biology, 2013 - Springer
… a variety of cell types that can live from months to years. An … change significantly across
different brain regions (temporal … While future studies could account for sequence differences, …