A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data

H Feng, KN Conneely, H Wu - Nucleic acids research, 2014 - academic.oup.com
… For the comparison of DNA methylation levels between … nucleotide resolution DNA-methylation
data for comparisons of … parameter, and several algorithms were developed to shrink the …

[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing

A Vidaki, D Ballard, A Aliferi, TH Miller… - Forensic Science …, 2017 - Elsevier
… age-associated DNA methylation differences in a way that the … libraries were then normalised
to 4 nM using Tris-HCL 10 mM… The unified genotyper algorithm was employed within GATK …

[HTML][HTML] De novo identification of differentially methylated regions in the human genome

TJ Peters, MJ Buckley, AL Statham, R Pidsley… - Epigenetics & …, 2015 - Springer
DNA methylation is widely regarded as the most stable epigenetic … With regards to real data,
we used two experimental comparisons … Even though the BSmooth algorithm takes a similar …

[HTML][HTML] Whole slide images reflect DNA methylation patterns of human tumors

H Zheng, A Momeni, PL Cedoz, H Vogel… - NPJ genomic …, 2020 - nature.com
… We demonstrate that classical machine learning algorithms can associate the DNA methylation
… We show results in two different cancer sites, glioma and renal cell carcinoma (RCC). …

DNA methylation analysis techniques

C Dahl, P Guldberg - Biogerontology, 2003 - Springer
… In this review, we describe different ways of analyzing DNA methylation and outline the …
techniques for gene-specific analysis of DNA methylation. Each of these techniques is limited in …

Tumour class prediction and discovery by microarray-based DNA methylation analysis

P Adorján, J Distler, E Lipscher, F Model… - Nucleic acids …, 2002 - academic.oup.com
… We then trained the learning algorithm (SVM) to recognise the difference between T and B
cell leukaemias (from both patient samples and cell lines) and CD19 + B cells and CD4 + T …

Disease prediction by cell-free DNA methylation

H Feng, P Jin, H Wu - Briefings in bioinformatics, 2019 - academic.oup.com
… setting, the methylation differences come from the differences in mixing proportions …
reference-based algorithms that specifically designed for gene expression or DNA methylation data, …

[HTML][HTML] Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders

…, J Masters, M Kadour, MJ Friez, MM van Haelst… - Genetics in …, 2021 - nature.com
… -CAN]”), which will compare the impact of DNA methylation analysis as a first-line versus a
algorithms. As the EKD expands, the reference machine learning–derived algorithms that …

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

L Milani, A Lundmark, A Kiialainen… - Blood, The Journal …, 2010 - ashpublications.org
… This algorithm performs the clustering by a divisive (top-down) procedure, in which the …
Table 3 lists the genes that displayed a median CpG site methylation difference of 0.3 or greater …

[HTML][HTML] Diagnostic utility of genome-wide DNA methylation testing in genetically unsolved individuals with suspected hereditary conditions

E Aref-Eshghi, EG Bend, S Colaiacovo… - The American Journal of …, 2019 - cell.com
… of genome-wide DNA methylation analysis of peripheral blood … of 14 syndromes using DNA
methylation data with full accuracy. … This study demonstrates that genomic DNA methylation