Substantial DNA methylation differences between two major neuronal subtypes in human brain

A Kozlenkov, M Wang, P Roussos… - Nucleic acids …, 2016 - academic.oup.com
… CpG methylation. Regions that are differentially methylated in GABA and GLU neurons were
… Collectively, our findings suggest that functional differences between neuronal subtypes are …

Principles governing DNA methylation during neuronal lineage and subtype specification

A Sharma, SL Klein, L Barboza, N Lodhi… - Journal of …, 2016 - Soc Neuroscience
main conclusion of our work is that the neuronal methylation/… when neuron subtype-specific
differences also emerge. … rules that govern DNA methylation and demethylation in neuronal

Evolution of DNA methylation in the human brain

H Jeong, I Mendizabal, S Berto, P Chatterjee… - Nature …, 2021 - nature.com
DNA methylation changes during recent human brain evolution. We demonstrate dynamic
evolutionary trajectories of DNA methylationmethylation patterns of neuronal subtypes for CH …

DNA methylation profiling of human prefrontal cortex neurons in heroin users shows significant difference between genomic contexts of hyper-and hypomethylation …

A Kozlenkov, AE Jaffe, A Timashpolsky, P Apontes… - Genes, 2017 - mdpi.com
different neuronal subtypes and different genomic contexts. These observations imply that
different … regulation might be recruited in different neuronal subtypes or specifically targeted to …

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex

G Gasparoni, S Bultmann, P Lutsik, TFJ Kraus… - Epigenetics & …, 2018 - Springer
… The aim of this study is to address DNA methylation changes … , we performed an initial DNA
methylation screen on unsorted … To calculate the association between DNA methylation and …

Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex

C Luo, CL Keown, L Kurihara, J Zhou, Y He, J Li… - Science, 2017 - science.org
neuronal diversity in human, revealed by DNA methylation … potential dorsal origin of certain
interneuron subtypes (15, 24, 25). … the DNA methylation–based neuronal populations defined …

Neuronal activity modifies the DNA methylation landscape in the adult brain

JU Guo, DK Ma, H Mo, MP Ball, MH Jang… - Nature …, 2011 - nature.com
methylation changes for a defined mature neuronal subtype in vivo. Together with the gene
expression profiles, these data sets will serve as a resource for the neuroscience community. …

Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene

M Nishioka, T Shimada, M Bundo, W Ukai… - International Journal of …, 2013 - Elsevier
… will be critically important. Here we examined DNA methylation status of CpG islands and
a CpG island shore on mouse Cacna1c in neuronal and non-neuronal nuclei, which were …

The role of DNA methylation in the central nervous system and neuropsychiatric disorders

J Feng, G Fan - International review of neurobiology, 2009 - Elsevier
… toxic, subtypeneuronal DNA methylation change under both physiological and pathological
conditions will further improve our understanding of the role of DNA methylation in neural

Cell type-specific DNA methylome signatures reveal epigenetic mechanisms for neuronal diversity and neurodevelopmental disorder

Y Jin, K Su, HE Kong, W Ma, Z Wang… - Human Molecular …, 2023 - academic.oup.com
… Our results suggest that cell type-specific DNA methylation signatures are associated with …
the neuronal subtypes. The presented results emphasize the importance of DNA methylation-…