DNA methylation signature of human fetal alcohol spectrum disorder

E Portales-Casamar, AA Lussier, MJ Jones… - Epigenetics & …, 2016 - Springer
… observed in children with fetal alcohol spectrum disorder (FASD). Thus, we investigated the
effects of prenatal alcohol exposure on genome-wide DNA methylation in the NeuroDevNet …

DNA methylation as a predictor of fetal alcohol spectrum disorder

AA Lussier, AM Morin, JL MacIsaac, J Salmon… - Clinical …, 2018 - Springer
DNA methylation profiles could be used to identify individuals with FASD, generating a
classification algorithm that uses DNA methylation levels … differences in DNA methylation patterns …

DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes

JM Cobben, IM Krzyzewska, A Venema, AN Mul… - …, 2019 - Taylor & Francis
prenatal exposure to alcohol on the fetal development is a severe, prevalent and worldwide
medical issue. The term fetal alcohol spectrum disorders (… , of which fetal alcohol syndrome (…

Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders

BI Laufer, EJ Chater-Diehl, J Kapalanga, SM Singh - Alcohol, 2017 - Elsevier
… that prenatal alcohol exposure alters DNA methylation. … mechanisms of the epigenome
is DNA methylation: a highly dynamic … The most widely studied DNA methylation mark is 5-…

Associative DNA methylation changes in children with prenatal alcohol exposure

BI Laufer, J Kapalanga, CA Castellani, EJ Diehl… - …, 2015 - Taylor & Francis
… some identical changes in DNA methylation in the buccal swabs … with FASD have unique
DNA methylation defects that can be … cluster in six fetal alcohol spectrum disorders children and …

Epigenetic clock analysis in children with fetal alcohol spectrum disorder

S Okazaki, I Otsuka, Y Shinko, T Horai… - Alcoholism: Clinical …, 2021 - Wiley Online Library
… aging in fetal alcohol spectrum disorder (FASD), and performed analyses using epigenetic
clocks that estimate biological aging based on genome-wide DNA methylation profiles. We …

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?

AA Lussier, J Weinberg, MS Kobor - Epigenomics, 2017 - Taylor & Francis
… and identifying alterations to bulk levels of DNA methylation in different brain regions under
basal … delays the accumulation of DNA methylation in neural stem cells, and increases DNA

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice

BI Laufer, K Mantha, ML Kleiber… - Disease models & …, 2013 - journals.biologists.com
Fetal alcohol spectrum disorders (FASDs) are characterized by life-long changes in gene
expression, neurodevelopment and behavior. What mechanisms initiate and maintain these …

Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome

AJ Garro, DL McBeth, V Lima… - Alcoholism: Clinical and …, 1991 - Wiley Online Library
… Since DNA methylation is thought to play an important role in the regulation … fetal DNA
methylation may contribute to the developmental abnormalities seen in the fetal alcohol syndrome. …

Hippocampal DNA methylation in a mouse model of fetal alcohol spectrum disorder that includes maternal separation stress only partially explains changes in gene …

BLJ Alberry, SM Singh - Frontiers in Genetics, 2020 - frontiersin.org
… , here we focus on promoter DNA methylation that may repress transcription … DNA methylation
(Jaenisch and Bird, 2003). This research is novel in that it combines the effect of prenatal