… the development of DNMT inhibitors that do not require DNA … Although many questions
remain open, the DNA methylation … to have an impact on human disease. These classes of drugs …

… Epigenetic modification, in particular DNA methylation, represents a mechanism … of human
disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation …

… for treatment of human disease. The most well established therapies alter DNA methylation
and … The DNMTIs, 5-azacytadine, and decitabine, were originally developed in the 1960s as …

… of DNA methylation, its role in neurodevelopment functions, and how assessment of DNA
hypermethylation and … This review also paves the way for the development of novel treatment …

… for aberrant DNA methylation processes … DNA methylation, with particular focus on
neurodegenerative diseases, together with a short description of the state-of-the-art of methylation …

… 4Broader changes in genomic DNA methylation patterns occur during development, in
germ … Phenotypic plasticity and the epigenetics of human disease. Nature 2007; 447: 433-440. …

… The hypothesis that DNA methylation changes are driving human disease and health … with
pharmacological or behavioral interventions maladaptive DNA methylation marks. As several …

… potential insights for human disease onset and progression. In this review, we summarize
recent milestones in characterizing the human genetic basis of DNA methylation variation over …

… summarize all available evidence related to the association between DNA methylation
and CHD. We selected studies that analyzed DNA methylation at either a global or gene-specific …

… as a surrogate marker of global DNA methylation. Altered maternal DNA methylation is
suggested to be an underlying mechanism in the trisomy 21 and the development of birth defects, …