Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline

JA Hackett, JP Reddington, CE Nestor… - …, 2012 - journals.biologists.com
… To investigate the dynamics of DNA methylation at germline genome-defence genes during
PGC development in vivo, we tracked the methylation status and expression of these genes …

DNA methylation in the vertebrate germline: balancing memory and erasure

O Ortega-Recalde, TA Hore - Essays in biochemistry, 2019 - portlandpress.com
… defined germline of chicken to preserve DNA methylation in PGCs, but that salamanders
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …

Placeholder nucleosomes underlie germline-to-embryo DNA methylation reprogramming

PJ Murphy, SF Wu, CR James, CL Wike, BR Cairns - Cell, 2018 - cell.com
… Thus, the paternally inherited DNA methylation patterns of zebrafish sperm are compatible …
the derivation of germline. Likewise, zebrafish oocytes lack DNA methylation at housekeeping …

DNA methylation dynamics in the female germline and maternal-effect mutations that disrupt genomic imprinting

Z Anvar, I Chakchouk, H Demond, M Sharif, G Kelsey… - Genes, 2021 - mdpi.com
… key milestones in DNA methylation patterning in the female germline and the embryo focusing
on humans. We provide an overview of recent findings regarding DNA methylation deficits …

Maternal vitamin C regulates reprogramming of DNA methylation and germline development

SP DiTroia, M Percharde, MJ Guerquin, E Wall… - Nature, 2019 - nature.com
… acid) in the developing germline, which expresses high … test the role of vitamin C in germline
development (see Methods). … of global DNA methylation during germline reprogramming 3 …

DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

M Schulz, A Teissandier… - Nature Structural & …, 2024 - nature.com
DNA methylation-sensitive TFs. We propose that DNA methylation is required at a subset
of DNA methylation-sensitive enhancers to limit an early coordinated neural–germline fate as …

Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

O Ortega-Recalde, RC Day, NJ Gemmell… - Nature …, 2019 - nature.com
DNA methylation dynamics in the zebrafish germline throughout development. In stark
contrast to mammals, we find DNA methylation is not erased at any stage of germlinegermline

DNA methylation from germline cells in veterans with PTSD

D Mehta, ES Pelzer, D Bruenig, B Lawford… - Journal of psychiatric …, 2019 - Elsevier
… 7 DNA methylation in Holocaust survivors and significantly lower FKBP5 intron 7 DNA methylation
in their … These findings suggest that trauma-induced DNA methylation changes can be …

HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination

MI Sigurdsson, AV Smith, HT Bjornsson… - Genome …, 2009 - genome.cshlp.org
germline DNA methylation might be the prime epigenetic mechanism affecting meiotic
recombination. Methylation … We chose to focus our efforts on germline DNA methylation and took a …

DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… patterns, transcription profiles, and chromatin modifications, including silencing of pluripotency
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …