Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline
… To investigate the dynamics of DNA methylation at germline genome-defence genes during
PGC development in vivo, we tracked the methylation status and expression of these genes …
PGC development in vivo, we tracked the methylation status and expression of these genes …
DNA methylation in the vertebrate germline: balancing memory and erasure
O Ortega-Recalde, TA Hore - Essays in biochemistry, 2019 - portlandpress.com
… defined germline of chicken to preserve DNA methylation in PGCs, but that salamanders
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …
and axolotls show epigenetic erasure on account of their germline defined by induction [104]. …
Placeholder nucleosomes underlie germline-to-embryo DNA methylation reprogramming
… Thus, the paternally inherited DNA methylation patterns of zebrafish sperm are compatible …
the derivation of germline. Likewise, zebrafish oocytes lack DNA methylation at housekeeping …
the derivation of germline. Likewise, zebrafish oocytes lack DNA methylation at housekeeping …
DNA methylation dynamics in the female germline and maternal-effect mutations that disrupt genomic imprinting
… key milestones in DNA methylation patterning in the female germline and the embryo focusing
on humans. We provide an overview of recent findings regarding DNA methylation deficits …
on humans. We provide an overview of recent findings regarding DNA methylation deficits …
Maternal vitamin C regulates reprogramming of DNA methylation and germline development
SP DiTroia, M Percharde, MJ Guerquin, E Wall… - Nature, 2019 - nature.com
… acid) in the developing germline, which expresses high … test the role of vitamin C in germline
development (see Methods). … of global DNA methylation during germline reprogramming 3 …
development (see Methods). … of global DNA methylation during germline reprogramming 3 …
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
M Schulz, A Teissandier… - Nature Structural & …, 2024 - nature.com
… DNA methylation-sensitive TFs. We propose that DNA methylation is required at a subset
of DNA methylation-sensitive enhancers to limit an early coordinated neural–germline fate as …
of DNA methylation-sensitive enhancers to limit an early coordinated neural–germline fate as …
Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
… DNA methylation dynamics in the zebrafish germline throughout development. In stark
contrast to mammals, we find DNA methylation is not erased at any stage of germline … germline …
contrast to mammals, we find DNA methylation is not erased at any stage of germline … germline …
DNA methylation from germline cells in veterans with PTSD
… 7 DNA methylation in Holocaust survivors and significantly lower FKBP5 intron 7 DNA methylation
in their … These findings suggest that trauma-induced DNA methylation changes can be …
in their … These findings suggest that trauma-induced DNA methylation changes can be …
HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination
… germline DNA methylation might be the prime epigenetic mechanism affecting meiotic
recombination. Methylation … We chose to focus our efforts on germline DNA methylation and took a …
recombination. Methylation … We chose to focus our efforts on germline DNA methylation and took a …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
… patterns, transcription profiles, and chromatin modifications, including silencing of pluripotency
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …
genes and germline-specific genes by DNA methylation [7]. At this point, PGCs display …