Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
… We conclude that somatic cells show a systematic methylation of promoters for germline-specific
genes, including strong CpG islands that are otherwise protected from …
genes, including strong CpG islands that are otherwise protected from …
DNA methylation reprogramming of genomic imprints in the mammalian germline: A TET‐centric view
BA Caldwell, MS Bartolomei - Andrology, 2023 - Wiley Online Library
… that are critical to achieving a DNA hypomethylated state, with … DNA methylation dynamics
in the mammalian genome, with a particular emphasis on DNA demethylation in the germline …
in the mammalian genome, with a particular emphasis on DNA demethylation in the germline …
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
A Hazra, CS Fuchs, T Kawasaki, GJ Kirkner… - Cancer causes & …, 2010 - Springer
… CpG island methylation in colorectal … germline nonsynonymous SNPs (nsSNPs) in 12
one-carbon metabolism genes and DNA methylation status (CIMP status and LINE-1 methylation) …
one-carbon metabolism genes and DNA methylation status (CIMP status and LINE-1 methylation) …
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
… gene family that are regulated by their promoter DNA methylation [12, 13], were … of DNA
methyltransferases is necessary for their expression. We confirmed retention of DNA methylation …
methyltransferases is necessary for their expression. We confirmed retention of DNA methylation …
De novo DNA methylation: a germ cell perspective
SA Smallwood, G Kelsey - Trends in Genetics, 2012 - cell.com
… Elucidating how DNA methylation marks are established in the germline has been a
challenge for nearly 20 years, but represents a key step towards a full understanding of several …
challenge for nearly 20 years, but represents a key step towards a full understanding of several …
[HTML][HTML] Sequences sufficient for programming imprinted germline DNA methylation defined
… DNA methylation from the maternal allele [18]. H19 DNA methylation acquired in the germline
… is necessary for establishing methylation at the adjacent DMD in the male germline [22]. …
… is necessary for establishing methylation at the adjacent DMD in the male germline [22]. …
[HTML][HTML] High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats
SS Deshpande, H Nemani, G Arumugam… - Clinical …, 2020 - Springer
… To study the effect of high-fat diet-induced and genetically inherited obesity on DNA methylation
in the male germline, we first assessed the DNA methyltransferases expression pattern …
in the male germline, we first assessed the DNA methyltransferases expression pattern …
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development
R Yan, X Cheng, C Gu, Y Xu, X Long, J Zhai, F Sun… - Nature Genetics, 2023 - nature.com
… novo or maintenance DNA methylation in mouse zygotes remains debatable 9 . Moreover,
although a small repertoire of maternal genes are known to affect DNA methylation in mouse …
although a small repertoire of maternal genes are known to affect DNA methylation in mouse …
DNA methylation-associated repression of cancer-germline genes in human embryonic and adult stem cells
… Cancer-germline (CG) genes are a particular group of germline-specific genes that rely
primarily on DNA methylation for repression in somatic tissues. In a wide variety of tumors, the …
primarily on DNA methylation for repression in somatic tissues. In a wide variety of tumors, the …
[HTML][HTML] DNA methylation imprints on the IG-DMR of the Dlk1–Gtl2 domain in mouse male germline
H Hiura, J Komiyama, M Shirai, Y Obata, H Ogawa… - FEBS letters, 2007 - Elsevier
… and Gtl2 is specifically methylated in the male germline; IG-DMR regulates the parental …
methylation marks during male germ-cell differentiation. For parental allele-specific methylation …
methylation marks during male germ-cell differentiation. For parental allele-specific methylation …