[HTML][HTML] Effect of disease-associated germline mutations on structure function relationship of DNA methyltransferases
… germline-transmitted and associated with a number of hereditary disorders, which are
potentially caused by aberrant DNA methylation … and regulation of DNA methylation and DNMTs. …
potentially caused by aberrant DNA methylation … and regulation of DNA methylation and DNMTs. …
SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation
A Zoch, T Auchynnikava, RV Berrens, Y Kabayama… - Nature, 2020 - nature.com
… germline reprogramming and de novo genome methylation to reset genomic DNA methylation
… In the male germline of mice, the process of de novo DNA methylation occurs in gonocytes…
… In the male germline of mice, the process of de novo DNA methylation occurs in gonocytes…
[HTML][HTML] Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients
NY Lee, M Hum, GP Tan, AC Seah, PY Ong, PT Kin… - Clinical …, 2024 - Springer
… Here, we aimed to identify blood-based DNA methylation biomarkers that are associated …
blood DNA methylation, as it is easy to collect and process especially relative to cell-free DNA. …
blood DNA methylation, as it is easy to collect and process especially relative to cell-free DNA. …
Germline histone dynamics and epigenetics
SL Ooi, S Henikoff - Current opinion in cell biology, 2007 - Elsevier
… Germline chromatin undergoes a series of dramatic remodeling events during the life cycle
of an organism. Different aspects of germline … are independent of DNA methylation. Taken …
of an organism. Different aspects of germline … are independent of DNA methylation. Taken …
Evolutionary expansion of DNA hypomethylation in the mammalian germline genome
… We compared whole-genome, single-CpG DNA methylation … We developed a phylo-epigenetic
model for DNA methylation that … our understanding of DNA methylation divergence. …
model for DNA methylation that … our understanding of DNA methylation divergence. …
Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes
SO Antwi, M Heckman, L White, I Yan… - Human molecular …, 2023 - academic.oup.com
… is also implicated in DNA methylation through the production … that is used for DNA methylation
(covalent attachment of a … one-carbon metabolism and DNA methylation, it is important …
(covalent attachment of a … one-carbon metabolism and DNA methylation, it is important …
DNA methylation and histone post-translational modifications in the mouse germline following in-vitro maturation of fresh or cryopreserved prepubertal testicular tissue
A Oblette, J Rondeaux, L Dumont, M Delessard… - Reproductive …, 2019 - Elsevier
… This study investigated the expression of epigenetic modification enzymes, DNA methylation
and histone PTM, and the spermatogenic progression after in-vitro maturation of fresh or …
and histone PTM, and the spermatogenic progression after in-vitro maturation of fresh or …
Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant germline gene activation
G Lea, CW Hanna - BioEssays, 2024 - Wiley Online Library
… We hypothesize that de-repression of germline genes upon loss of DNA methylation in the
Dnmt3b KO may underpin aspects of the impaired placental labyrinth formation by interfering …
Dnmt3b KO may underpin aspects of the impaired placental labyrinth formation by interfering …
[HTML][HTML] Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA
… because mammals erase epigenetic information by germline reprogramming. We sequenced
the … in mammals the plant germline retains CG and CHG DNA methylation. However, CHH …
the … in mammals the plant germline retains CG and CHG DNA methylation. However, CHH …
The DNA methylation paradox
PA Jones - Trends in genetics, 1999 - cell.com
… The methylation of CpG islands is often equated with … methylation paradox might be resolved
if it is hypothesized that transcription through a CpG island facilitates de novo methylation…
if it is hypothesized that transcription through a CpG island facilitates de novo methylation…