[HTML][HTML] Effect of disease-associated germline mutations on structure function relationship of DNA methyltransferases

AB Norvil, D Saha, MS Dar, H Gowher - Genes, 2019 - mdpi.com
germline-transmitted and associated with a number of hereditary disorders, which are
potentially caused by aberrant DNA methylation … and regulation of DNA methylation and DNMTs. …

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation

A Zoch, T Auchynnikava, RV Berrens, Y Kabayama… - Nature, 2020 - nature.com
germline reprogramming and de novo genome methylation to reset genomic DNA methylation
… In the male germline of mice, the process of de novo DNA methylation occurs in gonocytes…

[HTML][HTML] Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients

NY Lee, M Hum, GP Tan, AC Seah, PY Ong, PT Kin… - Clinical …, 2024 - Springer
… Here, we aimed to identify blood-based DNA methylation biomarkers that are associated …
blood DNA methylation, as it is easy to collect and process especially relative to cell-free DNA. …

Germline histone dynamics and epigenetics

SL Ooi, S Henikoff - Current opinion in cell biology, 2007 - Elsevier
Germline chromatin undergoes a series of dramatic remodeling events during the life cycle
of an organism. Different aspects of germline … are independent of DNA methylation. Taken …

Evolutionary expansion of DNA hypomethylation in the mammalian germline genome

J Qu, E Hodges, A Molaro, P Gagneux… - Genome …, 2018 - genome.cshlp.org
… We compared whole-genome, single-CpG DNA methylation … We developed a phylo-epigenetic
model for DNA methylation that … our understanding of DNA methylation divergence. …

Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes

SO Antwi, M Heckman, L White, I Yan… - Human molecular …, 2023 - academic.oup.com
… is also implicated in DNA methylation through the production … that is used for DNA methylation
(covalent attachment of a … one-carbon metabolism and DNA methylation, it is important …

DNA methylation and histone post-translational modifications in the mouse germline following in-vitro maturation of fresh or cryopreserved prepubertal testicular tissue

A Oblette, J Rondeaux, L Dumont, M Delessard… - Reproductive …, 2019 - Elsevier
… This study investigated the expression of epigenetic modification enzymes, DNA methylation
and histone PTM, and the spermatogenic progression after in-vitro maturation of fresh or …

Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant germline gene activation

G Lea, CW Hanna - BioEssays, 2024 - Wiley Online Library
… We hypothesize that de-repression of germline genes upon loss of DNA methylation in the
Dnmt3b KO may underpin aspects of the impaired placental labyrinth formation by interfering …

[HTML][HTML] Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA

JP Calarco, F Borges, MTA Donoghue, F Van Ex… - Cell, 2012 - cell.com
… because mammals erase epigenetic information by germline reprogramming. We sequenced
the … in mammals the plant germline retains CG and CHG DNA methylation. However, CHH …

The DNA methylation paradox

PA Jones - Trends in genetics, 1999 - cell.com
… The methylation of CpG islands is often equated with … methylation paradox might be resolved
if it is hypothesized that transcription through a CpG island facilitates de novo methylation