DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

M Esteller, MF Fraga, M Guo… - Human molecular …, 2001 - academic.oup.com
… Our results show that singly retained alleles of germline mutated genes are never
hypermethylated in inherited tumors. However, this epigenetic change is a frequent second ‘hit’, …

Comparative principles of DNA methylation reprogramming during human and mouse in vitro primordial germ cell specification

F von Meyenn, RV Berrens, S Andrews, F Santos… - Developmental cell, 2016 - cell.com
… as divergent mechanisms regulating the observed DNA methylation dynamics. This work …
in the germline, and describes the principles and dynamics of DNA methylation remodeling …

Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

J Mill, T Tang, Z Kaminsky, T Khare… - The American Journal of …, 2008 - cell.com
… Second, we performed a hypothesis-driven analysis of DNA methylation across candidate …
in the germline, we also used CpG-island microarrays to profile germline DNA methylation in …

Human germline: a new research frontier

MA Surani - Stem cell reports, 2015 - cell.com
… Mammalian germline also generates critical … in the germline; following fertilization, they
are subsequently detected as robust and heritable parent-of-origin-dependent DNA methylation

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

S Seisenberger, JR Peat, TA Hore… - … of the Royal …, 2013 - royalsocietypublishing.org
… different stages of the germline have recently been … DNA methylation reprogramming. Here,
we review novel insights into how DNA methylation is reprogrammed in the mouse germline

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

FP Fortes, H Kuasne, FA Marchi… - Brazilian Journal of …, 2015 - SciELO Brasil
methylation of several genes. This study aimed to identify the DNA methylation pattern of …
, SOX2, and SOX17) in 30 patients with germline TP53 mutations, 10 patients with wild-type …

DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells

H Guo, B Hu, L Yan, J Yong, Y Wu, Y Gao, F Guo… - Cell research, 2017 - nature.com
… Moreover, we found that DNA methylation levels of the promoter regions of germline-specific
genes, which are highly and specifically expressed in FGCs, are significantly lower in FGCs …

Epigenetic germline mosaicism in infertile men

S Laurentino, J Beygo, V Nordhoff… - Human molecular …, 2015 - academic.oup.com
… in the DNA methylation values … DNA methylation, whereas oligoasthenozoospermic samples
contained discrete populations of spermatozoa with either normal or abnormal methylation

Heritable DNA methylation marks associated with susceptibility to breast cancer

JE Joo, JG Dowty, RL Milne, EM Wong… - Nature …, 2018 - nature.com
… Mendelian-like inheritance of germline DNA methylation in … We aimed to scan the genome
for heritable methylation marks … wide DNA methylation measured in 210 peripheral blood DNA

DNA methylation in mammalian development and disease

W Dean, D Lucifero, F Santos - Birth Defects Research Part C …, 2005 - Wiley Online Library
… During DNA methylation erasure in the male germline, a testis-specific CCCTC-binding
factor-paralog gene, BORIS (Brother of the Regulator of Imprinted Sites) is dramatically …