DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis
M Esteller, MF Fraga, M Guo… - Human molecular …, 2001 - academic.oup.com
… Our results show that singly retained alleles of germline mutated genes are never
hypermethylated in inherited tumors. However, this epigenetic change is a frequent second ‘hit’, …
hypermethylated in inherited tumors. However, this epigenetic change is a frequent second ‘hit’, …
Comparative principles of DNA methylation reprogramming during human and mouse in vitro primordial germ cell specification
F von Meyenn, RV Berrens, S Andrews, F Santos… - Developmental cell, 2016 - cell.com
… as divergent mechanisms regulating the observed DNA methylation dynamics. This work …
in the germline, and describes the principles and dynamics of DNA methylation remodeling …
in the germline, and describes the principles and dynamics of DNA methylation remodeling …
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
… Second, we performed a hypothesis-driven analysis of DNA methylation across candidate …
in the germline, we also used CpG-island microarrays to profile germline DNA methylation in …
in the germline, we also used CpG-island microarrays to profile germline DNA methylation in …
Human germline: a new research frontier
MA Surani - Stem cell reports, 2015 - cell.com
… Mammalian germline also generates critical … in the germline; following fertilization, they
are subsequently detected as robust and heritable parent-of-origin-dependent DNA methylation …
are subsequently detected as robust and heritable parent-of-origin-dependent DNA methylation …
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers
… different stages of the germline have recently been … DNA methylation reprogramming. Here,
we review novel insights into how DNA methylation is reprogrammed in the mouse germline …
we review novel insights into how DNA methylation is reprogrammed in the mouse germline …
DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
… methylation of several genes. This study aimed to identify the DNA methylation pattern of …
, SOX2, and SOX17) in 30 patients with germline TP53 mutations, 10 patients with wild-type …
, SOX2, and SOX17) in 30 patients with germline TP53 mutations, 10 patients with wild-type …
DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells
… Moreover, we found that DNA methylation levels of the promoter regions of germline-specific
genes, which are highly and specifically expressed in FGCs, are significantly lower in FGCs …
genes, which are highly and specifically expressed in FGCs, are significantly lower in FGCs …
Epigenetic germline mosaicism in infertile men
S Laurentino, J Beygo, V Nordhoff… - Human molecular …, 2015 - academic.oup.com
… in the DNA methylation values … DNA methylation, whereas oligoasthenozoospermic samples
contained discrete populations of spermatozoa with either normal or abnormal methylation …
contained discrete populations of spermatozoa with either normal or abnormal methylation …
Heritable DNA methylation marks associated with susceptibility to breast cancer
… Mendelian-like inheritance of germline DNA methylation in … We aimed to scan the genome
for heritable methylation marks … wide DNA methylation measured in 210 peripheral blood DNA …
for heritable methylation marks … wide DNA methylation measured in 210 peripheral blood DNA …
DNA methylation in mammalian development and disease
W Dean, D Lucifero, F Santos - Birth Defects Research Part C …, 2005 - Wiley Online Library
… During DNA methylation erasure in the male germline, a testis-specific CCCTC-binding
factor-paralog gene, BORIS (Brother of the Regulator of Imprinted Sites) is dramatically …
factor-paralog gene, BORIS (Brother of the Regulator of Imprinted Sites) is dramatically …