Developmental windows of susceptibility for epigenetic inheritance through the male germline

L Ly, D Chan, JM Trasler - Seminars in cell & developmental biology, 2015 - Elsevier
… Initial studies showed that DNA methylation on the DMRs of imprinted genes that are
methylated in the male germline, different types of repeats and intergenic sequences is acquired …

A unique gene regulatory network resets the human germline epigenome for development

WWC Tang, S Dietmann, N Irie, HG Leitch, VI Floros… - Cell, 2015 - cell.com
… This unique gene regulatory network, established by SOX17 and BLIMP1, drives comprehensive
germline DNA demethylation by repressing DNA methylation pathways and activating …

DNA methylation homeostasis in human and mouse development

M Iurlaro, F von Meyenn, W Reik - Current opinion in genetics & …, 2017 - Elsevier
… all contribute to the diverse establishment of DNA methylation in the germline, and the
understanding of these complex interactions remains a challenging and exciting area of research. …

DNA methylation dynamics in the germline of the marsupial tammar wallaby, Macropus eugenii

T Ishihara, D Hickford, G Shaw, AJ Pask… - DNA …, 2019 - academic.oup.com
DNA methylation levels by measuring 5-methylcytosine expression, and mRNA expression
and protein localization of the key enzyme DNA … changes in DNA methylation was conserved …

Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm

P Navarro-Costa, P Nogueira, M Carvalho… - Human …, 2010 - academic.oup.com
… Both observations validate the selected experimental strategy and illustrate the feasibility
of using ejaculated sperm to assess the germline DNA methylation profile of spermatogenesis …

DNA methylation in insects: on the brink of the epigenomic era

KM Glastad, BG Hunt, SV Yi… - Insect molecular …, 2011 - Wiley Online Library
DNA methylation systems across insect taxa and synthesize functional inferences from studies
of DNA methylation … differential methylation in somatic tissues are less prone to germline

Functions of DNA methylation: islands, start sites, gene bodies and beyond

PA Jones - Nature reviews genetics, 2012 - nature.com
… to disease-causing mutations in the germline and cancer-causing mutations in somatic cells
… have escaped methylation in the germline so that their high CpG density is maintained 55 . …

Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation

J Gertz, KE Varley, TE Reddy, KM Bowling, F Pauli… - PLoS …, 2011 - journals.plos.org
… the impact that DNA sequence has on DNA methylation by analyzing methylation levels in
a … during development and the direct transmission of DNA methylation in the germline, and …

Timing, rates and spectra of human germline mutation

R Rahbari, A Wuster, SJ Lindsay, RJ Hardwick… - Nature …, 2016 - nature.com
… cell line demonstrates that DNA methylation and perhaps other cell type–specific factors
have a finer-grained role in influencing the precise location of mutations in specific cell types. …

[HTML][HTML] Navigating the DNA methylation landscape of cancer

A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation patterns are maintained by the daughter DNA through a maintenance
DNA methylation … Both de novo DNA methylation and maintenance DNA methylation are …