… Targeted de novo methylation of a CTCF loop anchor … DNA looping, causing altered gene
expression in the neighboring loop. Finally, we show that these tools can edit DNA methylation …

… Most CpGs in mammalian genomes remain methylated during development, but CpG …
Nearly half of the unmethylated CpG islands identified in mammalian genomes do not occur at …

… DNA methylation at position C5 of the pyrimidine ring of cytosine in mammalian genomes
has … such as epigenetic gene silencing and the maintenance of genome integrity. Aberrant …

… Genes constitute only a small proportion of the total mammalian genome, and the precise
control of their expression in the presence of an overwhelming background of noncoding DNA …

… gene expression, genomic imprinting, and X-chromosome inactivation. This article describes
how DNA methylation … Key exceptions to this global methylation of the mammalian genome …

… Second: the transposons and other repeated sequences that constitute a large fraction of
the mammalian genome [18]. Third: a number of genes are methylated in a tissue-specific …

… Despite the significance of DNA methylation in mammalian … of the large mammalian genome
into regions that are … factors to scan the genome in their search for appropriate targets [21]. …

… After implantation, a wave of global de novo methylation re-establishes the DNA
methylation patterns that will be maintained, in large part, in somatic tissues. Genome-wide …

… in gene expression without a change in nucleotide sequence) phenomena. Although extensive
in plants and mammals, the absence of detectable DNA methylation … tissue-specific gene …

… Fortunately, the recent development of targeted tools for manipulating DNA methylation … of
DNA methylation in the mammalian genome and explore the current state of DNA methylation-…