The DNA methylation landscape in cancer

K Skvortsova, C Stirzaker, P Taberlay - Essays in biochemistry, 2019 - portlandpress.com
… and advances to distinguish major and minor DNA methylation intermediates such as 5hmC
from 5mC [15,16], the field is building comprehensive maps of DNA methylation landscapes

DNA methylation landscapes: provocative insights from epigenomics

MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
methylated, as are gene bodies and intergenic DNA. e | The DNA methylation landscape of
… that genes are separated by long tracts of DNA that contain transposable elements and their …

Charting a dynamic DNA methylation landscape of the human genome

MJ Ziller, H Gu, F Müller, J Donaghey, LTY Tsai… - Nature, 2013 - nature.com
… In this study, we systematically investigated the DNA methylation state of most human … On
a global scale, human ES cells and their derivatives exhibit the highest DNA methylation levels…

The DNA methylation landscape of advanced prostate cancer

SG Zhao, WS Chen, H Li, A Foye, M Zhang… - Nature …, 2020 - nature.com
… Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole-genome …

[HTML][HTML] Navigating the DNA methylation landscape of cancer

A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation patterns are maintained by the daughter DNA through a maintenance
DNA methylation … Both de novo DNA methylation and maintenance DNA methylation are …

The DNA methylation landscape of human early embryos

H Guo, P Zhu, L Yan, R Li, B Hu, Y Lian, J Yan, X Ren… - Nature, 2014 - nature.com
… a, Averaged DNA methylation levels along the gene bodies and 15 kilobases (kb) … b,
Methylation landscape across each stage of human early embryos. The averaged DNA methylation

Neuronal activity modifies the DNA methylation landscape in the adult brain

JU Guo, DK Ma, H Mo, MP Ball, MH Jang… - Nature …, 2011 - nature.com
… Our study shows how the epigenetic DNA methylation landscape of mature neurons is rapidly
modified in response to external stimuli in vivo. Recent technical advances have enabled …

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

T Yuan, Y Jiao, S de Jong, RA Ophoff, S Beck… - PLoS …, 2015 - journals.plos.org
… integrating Illumina 450k DNA methylation with ENCODE data … that genome-wide DNA
methylation patterns change with age [1–… of the DNA methylation landscape in response to aging. …

The DNA methylation landscape of hematological malignancies: an update

P Blecua, L Martinez‐Verbo, M Esteller - Molecular Oncology, 2020 - Wiley Online Library
DNA methylation is a key epigenetic player in … DNA methylation in hematological malignancies
described in the current literature. We discuss in detail the dual role of DNA methylation

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

J Klughammer, B Kiesel, T Roetzer, N Fortelny… - Nature medicine, 2018 - nature.com
… of DNA methylation sequencing in large cohorts of routinely collected clinical FFPE tumor
samples. To put the DNA methylation data … us to identify DNA methylation patterns predictive of …