… DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation … which target DNA methylation to specific …

… groups to the DNA, which generally decrease expression of a gene (DNA methylation or …
Research in epigenomics has identified novel and heritable changes in DNA methylation, …

… compete with transcription factors for DNA access. Under typical physiological … DNA
polymerases. On these occasions, specific chromatin remodelers may facilitate DNA access to DNA …

… Recent work has demonstrated DNA methylation patterns suggestive of prognostic significance.
While current treatment standards rely heavily upon surgical resection, chemotherapy, …

… The second, DpnI, cleaves methylated (unreplicated) plasmid DNA. … DNA goes through one
round of semiconservative DNA … Replicated DNA is distinguished from input plasmid DNA …

This chapter outlines a systematic approach to biomarker development designed to cope
effectively with the US regulatory system, under which the products are brought to the market, …

… Insertion of the transgenic DNA into the chromosomal DNA, although usually occurring at
a single site, is not a benign process and can lead to translocations or massive deletions. …

… DNA methylation studies that demonstrate a direct link between abnormal DNA methylation
… It also appears that disease-specific DNA methylation patterns undergo unique changes in …

… Further elements that affect splicing and alternative splicing are promoter elements and
the factors bound to them, chromatin structure, nucleosome positioning, DNA methylation and …

… have a unique DNA methylation profile, the next section of the review will describe the
DNA methylation alterations seen in cancer due to both hyper- and hypo- methylation events. …