DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
… Among epigenetic modifications, DNA methylation requires … of DNA methylation, the effects
of aberrant methylation on gene … , as well as memory epigenetics in Alzheimer's disease. …

DNA methylation variability in Alzheimer's disease

Z Huo, Y Zhu, L Yu, J Yang, P De Jager, DA Bennett… - Neurobiology of …, 2019 - Elsevier
… variability in gene regulation and AD pathogenesis, our findings unravel the etiological
heterogeneity of the 2 hallmarks, and highlight the importance of studying both traits in future …

Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer's disease

N Kobayashi, S Shinagawa, H Niimura, H Kida… - Scientific reports, 2020 - nature.com
methylation-sensitive high-resolution melting (MS-HRM) analysis 11 , we reported that DNA
methylation … ) (n = 30), suggesting that DNA methylation in the COASY gene promoter region …

[PDF][PDF] DNA methylation alterations in Alzheimer's disease

AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
pathology has been focused on DNA methylation. To this end, several studies have characterized
DNA methylation … in confirmed Alzheimer disease. Arch Neurol 1998;55: 1449–55. 41. …

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease involving multiple
pathologic processes. AD is characterized by a progressive decline in cognitive functions. The …

DNA methylation in Alzheimer's disease: In brain and peripheral blood

X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most burdensome threats to public health today. Its
prevalence … with pathological AD by examining the association of dorsolateral prefrontal cortex …

Dynamics of DNA methylation in aging and Alzheimer's disease

HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
… of DNA methylation in neurodegenerative diseases, with a special focus on DNA methylation
… context of neurodegeneration and its potential role in aging and Alzheimer's disease (AD). …

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

D Mastroeni, A Grover, E Delvaux, C Whiteside… - Neurobiology of …, 2010 - Elsevier
DNA methylation is a vital … of DNA methylation and eight methylation maintenance factors
in entorhinal cortex layer II, a region exhibiting substantial Alzheimer's disease (AD) pathology

[HTML][HTML] Altered mitochondrial DNA methylation pattern in Alzheimer disease–related pathology and in Parkinson disease

M Blanch, JL Mosquera, B Ansoleaga, I Ferrer… - … journal of pathology, 2016 - Elsevier
… However, mtDNA methylation is not the subject of the same … samples with Alzheimer
disease-related pathology (stages I … 1 mice along with Alzheimer disease pathology progression …

Sex-specific DNA methylation differences in Alzheimer's disease pathology

L Zhang, JI Young, L Gomez, TC Silva… - Acta neuropathologica …, 2021 - Springer
DNA methylation is an important epigenetic modification that regulates … of DNA methylation
differences in AD neuropathology, by re-analyzing four recent epigenome-wide association