[HTML][HTML] Associations of serum DNA methylation levels of chemokine signaling pathway genes with mild cognitive impairment (MCI) and Alzheimer's disease (AD)

T Zou, X Zhou, Q Wang, Y Zhao, M Zhu, L Zhang… - Plos one, 2023 - journals.plos.org
DNA methylation is a major component of epigenetics, which is influenced by environmental
factors leading to progression of diseases and providing new directions on pathogenesis

DNA methylation level of the neprilysin promoter in Alzheimer's disease brains

K Nagata, T Mano, S Murayama, TC Saido, A Iwata - Neuroscience Letters, 2018 - Elsevier
… a pathologicalDNA methylation status of CpG islands in the NEP promoter and its expression
level in AD brains. We performed pyrosequencing analyses to detect the DNA methylation

Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer's dementia: a network Mendelian randomization analysis

D Liu, Y Wang, H Jing, Q Meng, J Yang - Epigenetics, 2022 - Taylor & Francis
… underlying the pathogenesis of Alzheimer’s dementia. Our findings shed light on the role
of DNA methylation in gene expression and in the development of Alzheimer’s dementia. …

Epigenetics in Alzheimer's disease: a focus on DNA modifications

N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
… the etiology of the disease. In this review we focus on discussing the roles of DNA methylation
and … for identifying changes in DNA modifications that are specific for AD pathology. In this …

Epigenetic dysregulation in Alzheimer's disease: cause or consequence?

DLA Van Den Hove, G Kenis, BPF Rutten - Epigenomics, 2014 - Taylor & Francis
… , represent critical factors in the pathogenesis of AD (eg, [… that DNA methylation patterns
associated with brain disorders … being able to use blood DNA methylation signatures for accurate …

Prediction of Alzheimer's disease based on deep neural network by integrating gene expression and DNA methylation dataset

C Park, J Ha, S Park - Expert Systems with Applications, 2020 - Elsevier
… We present a novel Alzheimer's disease prediction model … the association between gene
expression and DNA methylation. … gene expression and DNA methylation and found that it can …

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's disease

C Breen, LA Papale, LR Clark… - Alzheimer's & …, 2024 - Wiley Online Library
… levels alone cannot suffice to conclusively test for mechanisms of AD pathophysiology, our
data provide an essential substrate for future combined methylomic, genomic, transcriptomic, …

Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies

J Yang, L Yu, C Gaiteri, GP Srivastava… - The international journal …, 2015 - Elsevier
… the diagnosis of Alzheimer's disease. A primer for practicing … with pathological AD (Yu et
al., 2014a). We and others have also detected DNA methylation associations with AD pathology

DNA methylation and tag SNPs of the BDNF gene in conversion of amnestic mild cognitive impairment into Alzheimer's disease: a cross-sectional cohort study

B Xie, Z Liu, W Liu, L Jiang, R Zhang… - … of Alzheimer's …, 2017 - content.iospress.com
… , aberrant DNA methylation at BDNF gene has not been well demonstrated in the pathogenesis
of … This study will help to understand the pathogenesis of AD progression, and provide …

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

E Pishva, B Creese, AR Smith, W Viechtbauer… - Neurobiology of …, 2020 - Elsevier
… This study used epigenome-wide association study (EWAS) Illumina 450K DNA methylation
data that had already been generated in human postmortem brain tissue from donors in the …