Population-specificity of human DNA methylation

HB Fraser, LL Lam, SM Neumann, MS Kobor - Genome biology, 2012 - Springer
… demonstrate extensive population specificity in DNA methylation profiles near transcription
start sites. We observed these differences at three levels: the extent of DNA methylation, its …

DNA methylation-based variation between human populations

F Kader, M Ghai - Molecular genetics and genomics, 2017 - Springer
… in DNA methylation patterns between various populations (pop… variation in DNA methylation
among human population and … The primer sets targeted 15 CpG sites and Sp1 (specificity

Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer—a clinical biomarker discovery and validation …

SØ Jensen, N Øgaard, MBW Ørntoft, MH Rasmussen… - Clinical …, 2019 - Springer
… study based on DNA methylation profiles of more than 5000 tumours and blood cell
populations identified CRC-specific DNA methylation markers. The DNA methylation patterns of …

DNA Methylation as a Cancer‐Specific Biomarker: From Molecules to Populations

A Patel, JD Groopman, A Umar - … of the New York Academy of …, 2003 - Wiley Online Library
… and specificity.’20 The reproducibility, sensitivity and specificity of the method selected to
assess DNA methylation … Both the sensitivity and specificity of diagnostic tests depends on the …

DNA methylation profiling reveals the presence of population-specific signatures correlating with phenotypic characteristics

AK Giri, S Bharadwaj, P Banerjee… - Molecular Genetics and …, 2017 - Springer
… To the best of our knowledge, we are the first group to show population specificity using
genome wide methylation data of 421,914 methylation probes in Indian population that is …

Accounting for population stratification in DNA methylation studies

RT Barfield, LM Almli, V Kilaru, AK Smith… - Genetic …, 2014 - Wiley Online Library
… ‐wide methylation data. We first illustrate the potential for confounding due to population
stratification by demonstrating widespread associations between DNA methylation and race in …

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment

E Hodges, A Molaro, CO Dos Santos, P Thekkat… - Molecular cell, 2011 - cell.com
DNA methylation has been implicated as an epigenetic component of mechanisms that
stabilize cell-fate decisions. Here, we have characterized the methylomes of human female …

Methods for analysis of specific DNA methylation status

MJ Pajares, C Palanca-Ballester, R Urtasun… - Methods, 2021 - Elsevier
… from non CpG cytosines to assure specificity for converted DNA. The amplicon should be …
in DNA methylation or even the contribution of methylated DNA from heterogeneous population

DNA methylation contributes to natural human variation

H Heyn, S Moran, I Hernando-Herraez… - Genome …, 2013 - genome.cshlp.org
… Furthermore, we aimed to interrogate the tissue specificity of epitype–genotype associations
… , we aimed to determine DNA methylation differences between human populations and their …

Differential DNA methylation analysis optimally requires purified cell populations

MK Skinner - Fertility and sterility, 2016 - fertstert.org
… help provide cell specificity, the use of a mixed cell population in the analysis of DNA
methylation is a reflection of all cell types present. Therefore, changes in cell population number or …