… preimplantation development. Here we provide an insight that epigenetic reprogramming of
DNA methylation … To address this hypothesis, methylation states of three repetitive genomic …

… However, DNA methylation marks must be globally removed to allow for sexual … the
preimplantation embryo. Recent technological advances in genome-wide DNA methylation analysis …

… In this study, we have provided the first complete description of the cycle of methylation
reprogramming in mouse preimplantation embryos. This cycle is initiated shortly after sperm …

… This mechanism, which allows efficient erasure of global DNA methylation, is relevant in
multiple biological processes. In preimplantation embryos, erasure of DNA methylation marks …

… embryos compared to abnormal embryos. In conclusion, our results suggest that DNA methylation
reprogramming … Furthermore, abnormalities in the four-cell-specific DNA methylome in …

… regarding global and imprinted DNA methylation programming in the mouse and human. …
in mouse and human DNA methylation dynamics during gamete and preimplantation …

… During development epigenetic reprograming takes place during gametogenesis and then
again in the pre-implantation embryo. These two reprograming windows ensure genome-…

… extent to which early embryonic landscapes are conserved 8,9,10 . We present genome-scale
DNA methylation maps of human preimplantation development and embryonic stem cell …

… DNA methylation and gene expression. For the oocyte transcriptomes of humans and mice,
… Our data suggest that DNA methylation reprogramming plays important roles in mammalian …

… erasure of DNA methylation at imprinted … of pre-implantation embryos at a low level that is
undetectable by immunofluorescence analysis, is sufficient to maintain the DNA methylation of …