… on a fifth group of diseases, Rett syndrome and related … ' methylation marks. The identification
of mutations in MECP2 as being causal in Rett syndrome 3 , an X-linked dominant disorder…

… as measured by ChIP-seq analysis, as well as DNA methylation … DNA methylation that were
used in this initial unbiased search are now known to be insensitive to low level methylation …

… Rett syndrome (RTT) is one of the most common causes of intellectual and developmental
… elucidating the distinct DNA methylation landscape in the brain that may explain why …

… focus on Rett Syndrome caused by MECP2 mutations. This includes the history of the disease,
… Recently, we reported that not only MeCP2 but also other DNA methylation-related factors …

Epigenetic mechanisms, such as DNA methylation, regulate … disease. A prime example
involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett syndrome (…

… methylated DNA. Much … in Rett syndrome, a severe neurodevelopmental disorder that afflicts
one in 10,000–15,000 girls. Early studies suggested a connection between DNA methylation…

… DNA methylation at MeCP2 target synaptic genes is restored by EE, because the DNA
methylation … of methyl groups for DNA methylation, increases DNA methylation of the promoter …

… Most cancers also involve DNA methylation abnormalities, in particular unscheduled gene
silencing via DNA methylation at CpG island promoters. This review concerns Rett syndrome, …

… The gene codes for two isoforms of the methyl-CpG-binding protein (MeCP2, MeCP2B)
which are involved in transcriptional silencing through DNA methylation. The gene has 4 exons. …

… include DNA methylation, histone posttranslational modifications (PTMs) and noncoding
RNAs, which regulate gene expression without altering the corresponding DNA sequences (…