[HTML][HTML] Optimized screening of DNA methylation sites combined with gene expression analysis to identify diagnostic markers of colorectal cancer

Z Ye, G Song, J Liang, S Yi, Y Gao, H Jiang - BMC cancer, 2023 - Springer
Background The prognosis of patients with colorectal cancer is related to early detection.
However, commonly used screening markers lack sensitivity and specificity. In this study, we …

Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation

V Myrianthopoulos, PF Cartron, Z Liutkevičiūtė… - European journal of …, 2016 - Elsevier
… of DNA methylation-related biological events. In this study, the implementation of virtual
screeningDNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. …

Review of blood-based colorectal cancer screening: how far are circulating cell-free DNA methylation markers from clinical implementation?

MBW Ørntoft - Clinical colorectal cancer, 2018 - Elsevier
… CRC screening marker … DNA methylation marker candidates for CRC screening. On the
basis of a methodical literature search, the past, present, and future of cell-free DNA screening

[HTML][HTML] Virtues and weaknesses of DNA methylation as a test for cervical cancer prevention

AT Lorincz - Acta cytologica, 2016 - karger.com
… There have been relatively few validation studies of DNA methylation biomarkers in large
population-based screening studies, but an encouraging development more recently is the …

Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer

MA Clarke, P Luhn, JC Gage, C Bodelon… - … journal of cancer, 2017 - Wiley Online Library
DNA methylation testing of host genes in cytological specimens, offer promise as an objective
biomarker for cervical cancer screening … have identified increased DNA methylation of host …

DNA methylation analysis for screening and diagnostic testing in neurodevelopmental disorders

DE Godler, DJ Amor - Essays in Biochemistry, 2019 - portlandpress.com
DNA methylation is the process where methyl groups are added to DNA molecules which
changes the activity of the DNADNA methylation in cancer, the role of DNA methylation in the …

Current methylation screening methods

TK Wojdacz - Epigenomics, 2009 - Taylor & Francis
DNA methylation is the covalent addition of a methyl group to the cytosines … of DNA methylation
and genetics have occurred at the same time. However, for years, the field of methylation

[HTML][HTML] Analysis of DNA methylation status in bodily fluids for early detection of cancer

K Yokoi, K Yamashita, M Watanabe - International journal of molecular …, 2017 - mdpi.com
… studies that analyzed DNA methylation in bodily fluids as a less-invasive cancer
screening. … In this article, we reviewed studies that analyzed DNA methylation in less-invasively-…

Detection of fecal DNA methylation for colorectal neoplasia: does it lead to an optimal screening test?

T Nagasaka, A Goel, N Matsubara… - Acta medica …, 2006 - ousar.lib.okayama-u.ac.jp
… To test the validity and usefulness of fecal-based epigenetic marker screening, human
colorectal cancer has provided a good model for investigating whether DNA methylation can be …

[HTML][HTML] Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study

F Zhao, P Bai, J Xu, Z Li, S Muhammad, D Li, Z Zhang… - Molecular Cancer, 2023 - Springer
… To establish the utility of our methylation screening model, we compared it to conventional
serum biomarkers that have been used for the detection of CRC – serum carcinoembryonic …