… We then present the unique advantage of long-read sequencing in detecting base
modifications in native DNA and highlight the respective strengths and weaknesses of PacBio and …

… cleave the recognition sequence at the site of DNA methylation (CCGG … sequences [21].
This is the most time and cost-effective sequencing method and require minute amounts of DNA […

… increased methylation due to re-normalization of repressed chromatin in DNA methylation
valleys was positively correlated with gene expression. Large, partially methylated domains …

… information on genomic DNA methylation. The earliest … the methylation status of specific
DNA sequences. Particularly, optimization of the methods based on bisulfite modification of DNA …

… DNA methylation level. We then examined the effect of increased sequencing data on the CpG
density and methylation … From the entire 7.9 Gbp sequencing data, enrichment maps were …

… are required to fully analyze the DNA methylation sequence. Here, we describe the 'gold-…
-sequence DNA from mammalian cells in order to determine and quantify the methylation state …

… sequencing polymerase synthesis rates are sensitive to DNA primary and secondary structure
25 . Therefore, we hypothesized that methylated bases in a DNA … SMRT sequencing (Fig. 1…

… in our understanding of the role of DNA methylation in development 3 , transgeneration … to
profile DNA methylation 7 . With the advent and popularization of next-generation sequencing (…

… Here we describe methylation on … DNA methylation sequence composition and distribution.
We also describe the effect of various DNA methylation mutants on genome-wide methylation …

… sequencing-based DNA methylation methods revealed that all four methods yield largely
comparable methylation … to which sequencing-based DNA methylation profiles generated by …