DNA methylation signatures for breast cancer classification and prognosis

M Szyf - Genome medicine, 2012 - Springer
… Here, I review the scientific basis for using DNA methylation signatures in breast cancer …
role of DNA methylation in normal gene regulation, the aberrations in DNA methylation in cancer…

[PDF][PDF] Anatomy of DNA methylation signatures: Emerging insights and applications

E Chater-Diehl, SJ Goodman, C Cytrynbaum… - The American Journal of …, 2021 - cell.com
… While DNA methylation signatures have demonstrated … DNA methylation signatures in full,
ie, all CpG sites used in the predictive models, to allow any reader to validate the signature for …

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …

[PDF][PDF] DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia

ME Figueroa, S Lugthart, Y Li… - Cancer cell, 2010 - cell.com
… the presence of a common DNA methylation signature that is detected in the vast majority
of cases. The nature of the genes found in this common epigenetic signature, which included …

[PDF][PDF] DNA methylation signatures in development and aging of the human prefrontal cortex

S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
DNA methylation is strongly associated with genotypic variants and correlates with … and
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human …

[PDF][PDF] DNA methylation signatures within the human brain

C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
… normal DNA methylation might distinguish individual brain regions. We determined the
quantitative DNA methylation … Our data suggest that DNA methylation signatures distinguish brain …

DNA methylation signatures of the plant chromomethyltransferases

Q Gouil, DC Baulcombe - PLoS genetics, 2016 - journals.plos.org
DNA methylation in plants is traditionally partitioned into CG, CHG and CHH contexts (with
H any nucleotide but G). By investigating DNA methylation … of different methylation pathways …

DNA methylation signatures for chromatinopathies: current challenges and future applications

Z Awamleh, S Goodman, S Choufani, R Weksberg - Human Genetics, 2024 - Springer
… In this perspective, we describe the seminal DNA methylation signature research in … ,
phenotype and DNA methylation, and the future applications of DNA methylation signatures. …

Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors

H Hernandez-Vargas, MP Lambert, F Le Calvez-Kelm… - PloS one, 2010 - journals.plos.org
… Our study shows that HCC tumors exhibit specific DNA methylation signatures associated
with major risk factors and tumor progression stage, with potential clinical applications in …

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

S Ligthart, C Marzi, S Aslibekyan, MM Mendelson… - Genome biology, 2016 - Springer
… Furthermore, DNA methylation may also affect chromosome stability and alternative splicing,
two functional consequences of DNA methylation which we have not investigated in the …