DNA methylation signatures for breast cancer classification and prognosis
M Szyf - Genome medicine, 2012 - Springer
… Here, I review the scientific basis for using DNA methylation signatures in breast cancer …
role of DNA methylation in normal gene regulation, the aberrations in DNA methylation in cancer…
role of DNA methylation in normal gene regulation, the aberrations in DNA methylation in cancer…
[PDF][PDF] Anatomy of DNA methylation signatures: Emerging insights and applications
E Chater-Diehl, SJ Goodman, C Cytrynbaum… - The American Journal of …, 2021 - cell.com
… While DNA methylation signatures have demonstrated … DNA methylation signatures in full,
ie, all CpG sites used in the predictive models, to allow any reader to validate the signature for …
ie, all CpG sites used in the predictive models, to allow any reader to validate the signature for …
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017 - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …
performed epigenome-wide screening and validation to identify mortality-related DNAm …
[PDF][PDF] DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
ME Figueroa, S Lugthart, Y Li… - Cancer cell, 2010 - cell.com
… the presence of a common DNA methylation signature that is detected in the vast majority
of cases. The nature of the genes found in this common epigenetic signature, which included …
of cases. The nature of the genes found in this common epigenetic signature, which included …
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[PDF][PDF] DNA methylation signatures in development and aging of the human prefrontal cortex
S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
… DNA methylation is strongly associated with genotypic variants and correlates with … and
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human …
in de novo DNA methylation. Our results indicate that promoter DNA methylation in the human …
[PDF][PDF] DNA methylation signatures within the human brain
C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
… normal DNA methylation might distinguish individual brain regions. We determined the
quantitative DNA methylation … Our data suggest that DNA methylation signatures distinguish brain …
quantitative DNA methylation … Our data suggest that DNA methylation signatures distinguish brain …
DNA methylation signatures of the plant chromomethyltransferases
Q Gouil, DC Baulcombe - PLoS genetics, 2016 - journals.plos.org
… DNA methylation in plants is traditionally partitioned into CG, CHG and CHH contexts (with
H any nucleotide but G). By investigating DNA methylation … of different methylation pathways …
H any nucleotide but G). By investigating DNA methylation … of different methylation pathways …
DNA methylation signatures for chromatinopathies: current challenges and future applications
Z Awamleh, S Goodman, S Choufani, R Weksberg - Human Genetics, 2024 - Springer
… In this perspective, we describe the seminal DNA methylation signature research in … ,
phenotype and DNA methylation, and the future applications of DNA methylation signatures. …
phenotype and DNA methylation, and the future applications of DNA methylation signatures. …
Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
… Our study shows that HCC tumors exhibit specific DNA methylation signatures associated
with major risk factors and tumor progression stage, with potential clinical applications in …
with major risk factors and tumor progression stage, with potential clinical applications in …
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
… Furthermore, DNA methylation may also affect chromosome stability and alternative splicing,
two functional consequences of DNA methylation which we have not investigated in the …
two functional consequences of DNA methylation which we have not investigated in the …