Cross-talk between site-specific transcription factors and DNA methylation states

A Blattler, PJ Farnham - Journal of Biological Chemistry, 2013 - ASBMB
… Because DNA methylation is reversible, there is … by DNA-binding transcription factors. We
discuss several models that, by incorporating sequence motifs, CpG density, and methylation

Transcription factors as readers and effectors of DNA methylation

H Zhu, G Wang, J Qian - Nature Reviews Genetics, 2016 - nature.com
… Although proteins from cell extracts are in a more native state in the MS/MS-based approach,
the DNA probes used in this approach are typically generic and, therefore, sequence …

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… Sequence-specific TFs might also be involved in maintaining DNA methylation states. For
example, ZFP57, which binds to mCpGs, was found to be necessary for the maintenance of …

DNA methylation presents distinct binding sites for human transcription factors

S Hu, J Wan, Y Su, Q Song, Y Zeng, HN Nguyen… - elife, 2013 - elifesciences.org
… Because our goal was to identify DNA methylation-dependent binding activity, we developed
a competition assay on a protein microarray to identify TFs that prefer DNA motifs carrying …

Role of DNA methylation in modulating transcription factor occupancy

MT Maurano, H Wang, S John, A Shafer, T Canfield… - Cell reports, 2015 - cell.com
DNA methylation in the active modulation of TF binding, we quantified the effect of DNA
methylation … , an abundant TF with known methylation sensitivity that is capable of autonomous …

Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions

A Feldmann, R Ivanek, R Murr, D Gaidatzis… - PLoS …, 2013 - journals.plos.org
… To further test the relationship between occupancy and methylation state, we next focused
our analysis exclusively on CpGs that reside within a CTCF motif. We and others have …

[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors

JF Kribelbauer, XJ Lu, R Rohs, RS Mann… - Journal of molecular …, 2020 - Elsevier
… Consistently, aberrant DNA methylation patterns play a role in the loss of allele-specific … of
mammalian DNA methylation is transitioning between, rather than maintaining cellular states. …

Competition between DNA methylation and transcription factors determines binding of NRF1

S Domcke, AF Bardet, P Adrian Ginno, D Hartl… - Nature, 2015 - nature.com
states are instructive for TF binding remains mainly unknown 1,2 . To explore the contribution
of DNA methylation … in murine stem cells in the presence and absence of DNA methylation. …

Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns

C Marchal, B Miotto - Journal of cellular physiology, 2015 - Wiley Online Library
… at the genome scale, and nowadays at the single-base resolution, in different physiological
and pathological states, unraveled that local changes in DNA methylation contribute to cell-…

Function and information content of DNA methylation

D Schübeler - Nature, 2015 - nature.com
… b, A transcription factor binds specifically to the methylated state of its binding site. c, A
methylation-sensitive transcription factor … ) proteins bind to the methylated state, leading to indirect …