Cross-talk between site-specific transcription factors and DNA methylation states
A Blattler, PJ Farnham - Journal of Biological Chemistry, 2013 - ASBMB
… Because DNA methylation is reversible, there is … by DNA-binding transcription factors. We
discuss several models that, by incorporating sequence motifs, CpG density, and methylation …
discuss several models that, by incorporating sequence motifs, CpG density, and methylation …
Transcription factors as readers and effectors of DNA methylation
… Although proteins from cell extracts are in a more native state in the MS/MS-based approach,
the DNA probes used in this approach are typically generic and, therefore, sequence …
the DNA probes used in this approach are typically generic and, therefore, sequence …
Sensitivity of transcription factors to DNA methylation
… Sequence-specific TFs might also be involved in maintaining DNA methylation states. For
example, ZFP57, which binds to mCpGs, was found to be necessary for the maintenance of …
example, ZFP57, which binds to mCpGs, was found to be necessary for the maintenance of …
DNA methylation presents distinct binding sites for human transcription factors
… Because our goal was to identify DNA methylation-dependent binding activity, we developed
a competition assay on a protein microarray to identify TFs that prefer DNA motifs carrying …
a competition assay on a protein microarray to identify TFs that prefer DNA motifs carrying …
Role of DNA methylation in modulating transcription factor occupancy
MT Maurano, H Wang, S John, A Shafer, T Canfield… - Cell reports, 2015 - cell.com
… DNA methylation in the active modulation of TF binding, we quantified the effect of DNA
methylation … , an abundant TF with known methylation sensitivity that is capable of autonomous …
methylation … , an abundant TF with known methylation sensitivity that is capable of autonomous …
Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions
… To further test the relationship between occupancy and methylation state, we next focused
our analysis exclusively on CpGs that reside within a CTCF motif. We and others have …
our analysis exclusively on CpGs that reside within a CTCF motif. We and others have …
[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors
… Consistently, aberrant DNA methylation patterns play a role in the loss of allele-specific … of
mammalian DNA methylation is transitioning between, rather than maintaining cellular states. …
mammalian DNA methylation is transitioning between, rather than maintaining cellular states. …
Competition between DNA methylation and transcription factors determines binding of NRF1
… states are instructive for TF binding remains mainly unknown 1,2 . To explore the contribution
of DNA methylation … in murine stem cells in the presence and absence of DNA methylation. …
of DNA methylation … in murine stem cells in the presence and absence of DNA methylation. …
Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns
… at the genome scale, and nowadays at the single-base resolution, in different physiological
and pathological states, unraveled that local changes in DNA methylation contribute to cell-…
and pathological states, unraveled that local changes in DNA methylation contribute to cell-…
Function and information content of DNA methylation
D Schübeler - Nature, 2015 - nature.com
… b, A transcription factor binds specifically to the methylated state of its binding site. c, A
methylation-sensitive transcription factor … ) proteins bind to the methylated state, leading to indirect …
methylation-sensitive transcription factor … ) proteins bind to the methylated state, leading to indirect …
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