[HTML][HTML] Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer's Disease Mouse Model

S Lee, HJ Lee, JM Chun, B Jung, J Kim… - Journal of Integrative …, 2024 - imrpress.com
… , we confirmed the DNA methylation status and mRNA levels … In terms of DNA methylation
status, the methylation of genes, … no significant change in the methylation level of Akap2 was …

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

AR Smith, RG Smith, E Pishva, E Hannon… - Clinical …, 2019 - Springer
Alzheimer’s disease entorhinal cortex. We demonstrate that previous estimates of DNA
hypermethylation in ANK1 in Alzheimer’s disease … regression models looking for an association

Attempt to predict A/T/N-based Alzheimer's disease cerebrospinal fluid biomarkers using a peripheral blood DNA methylation clock

…, Alzheimer's Disease Neuroimaging … - … Alzheimer's disease …, 2020 - content.iospress.com
… blood DNA methylation clock, which reflects the effect of biological aging on DNA methylation
(DNAme) status … a predictive model for each of A/T/N binary statuses in AD patients using …

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

M Konki, M Malonzo, IK Karlsson, N Lindgren… - Clinical …, 2019 - Springer
… for Alzheimer’s disease (AD). The association of the disease status with DNA methylation
was examined with linear mixed effects model including gender, zygosity, age, and interaction …

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

JV Sanchez-Mut, E Aso, N Panayotis, I Lott, M Dierssen… - Brain, 2013 - academic.oup.com
… Spnb4 according to DNA methylation microarray values (C) and pyrosequencing (D) in the
frontal cortex of APP-PSEN1 and 3xTg-AD Alzheimer's disease mouse models in relation to …

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered
in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA

DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

G Shireby, EL Dempster, S Policicchio… - Nature …, 2022 - nature.com
… Our initial EWAS model leveraged matched DNA methylation data from both the DLPFC
and OCC for each donor to maximize power to detect cortical DMPs associated with AD …

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

R Lardenoije, DLA van den Hove, M Havermans… - Molecular and Cellular …, 2018 - Elsevier
… markers of DNA methylation and hydroxymethylation in a range of animal models of AD,
and their correlations with amyloid plaque load. Three transgenic mouse models, including the …

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

P Cronin, MJ McCarthy, ASP Lim, DP Salmon… - Alzheimer's & …, 2017 - Elsevier
… clock, and changes in DNA methylation have been reported in … We hypothesized that aberrant
DNA methylation may affect … Our results indicate that cycles of DNA methylation contribute …

[HTML][HTML] Association between DNA methylation of the BDNF promoter region and clinical presentation in Alzheimer's disease

T Nagata, N Kobayashi, J Ishii, S Shinagawa… - … cognitive disorders …, 2015 - karger.com
… study, we examined whether DNA methylation of the brain-… Alzheimer's disease (AD).
Methods: Of 20 patients with AD and 20 age-matched normal controls (NCs), the DNA methylation