Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species

SE Ross, J Vázquez-Marín, KRB Gert… - Nucleic Acids …, 2023 - academic.oup.com
… Here we extend our knowledge on DNA methylome remodelling … comparable DNA methylome
remodelling dynamics in … sperm methylome (∼90%; mCG), and oocyte methylome (∼75%…

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

LB Kinner-Bibeau, AL Sedlacek, MN Messmer… - Nature …, 2017 - nature.com
… ,9,32 , we hypothesized that DCs undergo methylome remodelling in response to gp96
immunization. We examined DNA methylation first in total CD91 + cells following immunization of …

Developmental remodelling of non-CG methylation at satellite DNA repeats

SE Ross, A Angeloni, FS Geng… - Nucleic Acids …, 2020 - academic.oup.com
… male and female gametes, remodelled during mid-blastula transition, and re-established
during gastrulation in all embryonic layers. Moreover, we identify DNA methyltransferase 3ba (…

Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

S Li, L Christiansen, K Christensen, TA Kruse… - Scientific reports, 2017 - nature.com
… Although these were mainly obtained from the DNA methylome of whole blood corrected
for cell composition, the identified pathways could reflect the generic aging-related epigenetic …

Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours

Z Fazal, R Singh, F Fang, E Bikorimana, H Baldwin… - Epigenetics, 2021 - Taylor & Francis
… We next analysed whether changes in DNA CpG methylation correlated with changes in
gene expression by integrative DNA methylome and transcriptome analysis. We created a data …

The myonuclear DNA methylome in response to an acute hypertrophic stimulus

F Von Walden, M Rea, CB Mobley… - Epigenetics, 2020 - Taylor & Francis
… We then analysed high-quality large-fragment DNA from purified myonuclei as well as … of
the DNA methylation landscape in skeletal muscle during acute skeletal muscle remodelling. …

Making sense of the ageing methylome

K Seale, S Horvath, A Teschendorff, N Eynon… - Nature Reviews …, 2022 - nature.com
methylome, including entropy and correlation networks. Here, we review these changes in
the ageing methylome … We detail the evidence linking DNA methylation to ageing phenotypes …

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

J Rodríguez-Ubreva, C de la Calle-Fabregat… - Annals of the …, 2019 - ard.bmj.com
… The DNA methylomes of … methylome correlate with DAS28, in which high-activity patients
are divergent from healthy controls in contrast to remission patients whose methylome is …

Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer

PC Taberlay, AL Statham, TK Kelly, SJ Clark… - Genome …, 2014 - genome.cshlp.org
… Here, we have integrated epigenome-wide maps of DNA methylomes and nucleosome
occupancy in prostate and breast normal and cancer cells to gain a more comprehensive …

Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis

WJ Locke, SJ Clark - Breast Cancer Research, 2012 - Springer
… The methylome of malignant lesions is remarkably similar between early lesions like … DNA
hypermethylation and that gene silencing is associated with repressive chromatin remodelling