… dopamine transporter gene (SLC6A3 (DAT1)) as a potential mediator of response to disulfiram
… -repeat genotype responded to disulfiram treatment and had significantly reduced cocaine…

… Interestingly, chronic treatment with when added directly to … disulfiram in abstinent alcoholics
as well as disulfiram over… [3H]dopamine via reversal of the dopamine transporter in rat …

… Cocaine inhibits a variety of neurotransmitter transporters, including the dopamine
transporter DAT (SLC6A3), the serotonin transporter SERT (SLC6A4), and the norepinephrine …

… , the authors recommended the close monitoring of patients during disulfiram treatment. This
report, while informative and carefully presented, is also limited by several factors inherent …

… disulfiram's inhibition of dopamine β-hydroxylase (DBH), the catecholamine biosynthetic
enzyme that converts dopamine (DA… ability to treat cocaine dependence. We tested the effects of …

… 1, disulfiram reduced extracellular NA in all brain regions analysed. Two hours after disulfiram
treatment, extracellular NA fell by 80%, 60%, 67% and 74%, in the mPF cortex, occipital …

… urine samples when in combination with disulfiram treatment for CD. We speculate that the
increased dopamine levels as a result of disulfiram therapy more easily saturate the lower …

… toward an important role of the brain dopamine and noradrenergic system in … disulfiram and
DBH genotype.For investigating the dopamine and noradrenergic impact in disulfiramtreated …

… Disulfiram, but not DDC, reacted very efficiently with synaptosomal protein thiols; both DDC-
and disulfiram-… be mediated by disulfiram, (2) the uptake of MPP + and dopamine by striatal …

… dopamine transport are expected to influence the vesicular uptake/release of many other
transmitters, an effect which may contribute, as a whole, to the clinical neurotoxicity of disulfiram…