Modeling DNA methylation dynamics with approaches from phylogenetics

JA Capra, D Kostka - Bioinformatics, 2014 - academic.oup.com
… of DNA methylation in distinct stages across differentiating cellular lineages. Changes in CpG
… of our methylation dynamics estimates enabled us to show that DNA sequence context of …

Dynamic changes in DNA methylation in ischemic tolerance

R Meller, A Pearson, RP Simon - Frontiers in neurology, 2015 - frontiersin.org
… methyl groups into genomic DNA was measured. As such increased methylation may be
due to dynamic DNA methylation or DNA methylation following DNA damage and repair, which …

Active turnover of DNA methylation during cell fate decisions

A Parry, S Rulands, W Reik - Nature Reviews Genetics, 2021 - nature.com
… enhancers, and can give rise to large-scale oscillatory dynamics. We discuss this
phenomenon and propose that DNA methylation turnover might facilitate key lineage decisions. …

DNA methylation landscapes: provocative insights from epigenomics

MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
Dynamic DNA methylation changes within the so-called weak CpG island category raise
interesting questions. Are weak CpG islands discrete, like CGIs, or do they reflect the sequence …

Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing

J Broche, G Kungulovski, P Bashtrykov… - Nucleic acids …, 2021 - academic.oup.com
… were tightly correlated with the dynamics of the DNA methylation deposition and its stability
… , but they indicate that introduced CGI methylation has the capacity to directly silence gene …

Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice

ME Blewitt, NK Vickaryous, A Paldi, H Koseki… - PLoS …, 2006 - journals.plos.org
… We have analysed the DNA methylation in mature gametes, zygotes, and blastocysts and …
, there is no DNA methylation in the blastocyst, suggesting that DNA methylation is not the …

Mapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome

J Gu, M Stevens, X Xing, D Li, B Zhang… - G3: Genes …, 2016 - academic.oup.com
DNA methylation levels of all the CpGs located in a VMR for each sample and then averaged
the DNA methylation … type if the average cell type DNA methylation level was below 30%. …

Integrating DNA methylation dynamics into a framework for understanding epigenetic codes

KE Szulwach, P Jin - Bioessays, 2014 - Wiley Online Library
… of questions regarding how the dynamic regulation of DNA methylation may be linked to the
… about the interaction between transcription factors and dynamic DNA methylation states. …

Dynamics of DNA methylation in aging and Alzheimer's disease

HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
… of DNA methylation in neurodegenerative diseases, with a special focus on DNA methylation
dynamicsDNA methylation dynamics. Genomic cytosine nucleotide (C) is converted to 5-…

Functional implications of dynamic DNA methylation for the developing, aging and diseased brain

G Zimmer-Bensch - The DNA, RNA, and Histone Methylomes, 2019 - Springer
… and transcriptional changes suggest that DNA methylation-… As DNA methylation and DNA
methyltransferases (DNMTs) … known functional implications dynamic DNA methylation and the …