Dynamic heterogeneity and DNA methylation in embryonic stem cells

ZS Singer, J Yong, J Tischler, JA Hackett, A Altinok… - Molecular cell, 2014 - cell.com
… abrupt, step-like dynamics due to cell state transitions and transcriptional bursts. Finally,
using perturbations, we observed that DNA methylation modulates the population fraction of …

Dynamic enhancer DNA methylation as basis for transcriptional and cellular heterogeneity of ESCs

Y Song, PR van den Berg, S Markoulaki, F Soldner… - Molecular cell, 2019 - cell.com
DNA methylation at the … Dynamic allele-specific DNA methylation at the two SEs was also
seen at different stages in preimplantation embryos, revealing that methylation heterogeneity

Dynamic DNA methylation: In the right place at the right time

C Luo, P Hajkova, JR Ecker - Science, 2018 - science.org
The classical model of cytosine DNA methylation (the … patterns and pervasive dynamics during
mammalian development. … Beyond the newly appreciated dynamics, regulatory roles for …

Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation

L Busto-Moner, J Morival, H Ren, A Fahim… - PLoS computational …, 2020 - journals.plos.org
… the genome on newly-formed DNA shortly after replication. In … rate at which DNA methylation
appears on nascent DNA post … a window is dynamic and temporally heterogeneous within a …

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

J Klughammer, B Kiesel, T Roetzer, N Fortelny… - Nature medicine, 2018 - nature.com
… To investigate the DNA methylation dynamics associated with glioblastoma disease
progression, we established a richly annotated dataset of patients with primary glioblastoma (IDH-…

Dynamics and context-dependent roles of DNA methylation

C Ambrosi, M Manzo, T Baubec - Journal of molecular biology, 2017 - Elsevier
DNA methylation and how this modification is regulated and discusses the dynamics of
genome-wide DNA methylation … to be clarified if heterogeneity of DNA methylation at these sites …

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

T Yuan, Y Jiao, S de Jong, RA Ophoff, S Beck… - PLoS …, 2015 - journals.plos.org
… By using a powerful algorithm to correct for cellular heterogeneity [15], we demonstrate that
most of the epigenetic drift, specially the age-hypermethylated component of it, is not caused …

Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics

S Komaki, H Ohmomo, T Hachiya, Y Sutoh, K Ono… - Clinical …, 2021 - Springer
… In the present study, broader odds ratios of dynamic CpGs and significant between-study
heterogeneity in these traits were observed among all four samples, also implying the higher …

Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis

J Tajbakhsh, D Stefanovski, G Tang… - Experimental cell …, 2015 - Elsevier
… of chromatin structure and relevant DNA expression in cellular … DNA methylation increased
in a linear fashion. As a result of this development we had observed distinct DNA methylation

Modeling DNA methylation profiles through a dynamic equilibrium between methylation and demethylation

G De Riso, DFG Fiorillo, A Fierro, M Cuomo, L Chiariotti… - Biomolecules, 2020 - mdpi.com
… pattern of DNA methylation was the result of a dynamic balance between DNA methylation
and … Despite the presence of this heterogeneity among cells, we and others described that the …