… and effective diagnostic tools that will enhance early cancer detection and enable the better
… the current knowledge about DNA methylation changes in early neoplasia, focusing on the …

… Our results provide new insights into the role of DNA methylation in the development of early
colonic neoplasia, and provide target candidates for the use of epigenetic profiling in CRC …

… Methylation changes in these genes may be ideal … Hence, in this study we conducted DNA
methylation screening of … the current gold standard in DNA methylation analysis and from this …

… Consequently, DNA methylation may represent an early and fundamental step in the …
neoplastic transformation. Further, an assessment of the methylation profiles within neoplastic …

… This finding has increased interest in use of drugs that can inhibit the process of DNA methylation
and … The functions of DNA methylation in mammalian cells remain poorly defined. Early …

… genes may serve as effective molecular markers for early detection, risk assessment and …
and therapy of colorectal neoplasia. Aberrant CGI methylation occurs early during colorectal …

… Using statistical models we also show that increased DNMT3B expression is an early
event in colorectal neoplastic progression, with a significant increase at the hyperplastic polyp …

… also non-neoplastic because the differences in the methylation levels of … neoplastic nature
and does not support a hyperplastic origin. Thus, the clear differences in the DNA methylation …

… Screening over the past decades for precancerous lesions, designated as cervical intra-epithelial
neoplasia (CIN), has allowed prevention through early intervention. Understanding the …

… DNA methylation patterns may also be predictors of … DNA methylation as a driving force
in colorectal neoplasia and its … DNA methylation is not only present in the early phases of …