… changes such as extracellular Aβ plaques and intracellular neurofibrillary pathology, which
… and progressive pathology which offers a potential target for early intervention. Early Aβ …

… These early signaling abnormalities are discussed in the context of synaptic pathophysiology
… Overall, we aim to update and expand the list of early neuronal signaling abnormalities …

… Significance: Synaptic degeneration, an early pathological feature in Alzheimer's disease
(AD), is closely correlated to impaired cognitive function and memory loss. Recent studies …

… We demonstrate that CSF p-tau231 increases early in development of AD pathology and
is a principal candidate for detecting incipient Aβ pathology for therapeutic trial application …

… Almost all of the AD patients in this study were reasonably early in the course of the
disease, suggesting that synapse loss is probably a fundamental part of the early pathological …

Alzheimer’s disease (AD) is the most common form of senile dementia, affecting 10% of
individuals older than 65 and nearly 50% of those older than 85. The prevalence of AD in the …

… The lesions of Alzheimer disease include accumulation of … The progression of tau pathology
is stepwise and stereotyped … Various clinico-pathological types of Alzheimer disease have …

… early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's
disease … and neuroregeneration in the early stages of Alzheimer's disease pathogenesis. …

Introduction We examine the role of brain apolipoprotein B (apoB) as a putative marker of
early tau pathology and cognitive decline. Methods Cerebrospinal fluid (CSF) samples from …

… II) toward limbic and association cortices as Alzheimer's disease evolves. However, the
mechanism involved in this hierarchical pattern of disease progression is unknown. We describe …