A multistep epigenetic switch enables the stable inheritance of DNA methylation states

HN Lim, A Van Oudenaarden - Nature genetics, 2007 - nature.com
… The other partial state occurs when there is a 'naked' switch region without DNA methylation
… OxyR binding does, however, block DNA methylation. As a result, the U O partial expression …

Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression

DR Donohoe, SJ Bultman - Journal of cellular physiology, 2012 - Wiley Online Library
… the role of epigenetics as a mechanistic link between energy metabolism and control of gene
… Mechanistically, epigenetics involves changes in either DNA methylation [which occurs …

A concerted DNA methylation/histone methylation switch regulates rRNA gene dosage control and nucleolar dominance

RJ Lawrence, K Earley, O Pontes, M Silva, ZJ Chen… - Molecular cell, 2004 - cell.com
… Here, we present evidence for an epigenetic switch in which concerted changes in promoter
… We next tested whether or not promoter DNA methylation was tightly correlated with H3K9 …

Genomic patterns of DNA methylation: targets and function of an epigenetic mark

M Weber, D Schübeler - Current opinion in cell biology, 2007 - Elsevier
DNA methylation on a genome-wide scale have given new insights into the biological function
of DNA methylation … we will not focus on aberrant DNA methylation in cancer, for which we …

[HTML][HTML] Epigenetic regulation of myofibroblast differentiation by DNA methylation

B Hu, M Gharaee-Kermani, Z Wu, SH Phan - The American journal of …, 2010 - Elsevier
DNA methylation, a key mechanism of repressing gene expression, is of particular … We
analyzed the extent and regulation of DNA methylation of the α-smooth muscle actin (α-SMA) …

Genomic imprinting–a model for roles of histone modifications in epigenetic control

KR McEwen, AC Ferguson-Smith - Epigenomics, 2009 - Springer
… acquisition of DNA methylation at CG … epigenetic control of gene activity and repression in
mammals, and the functional relationship between histone modifications and DNA methylation

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

T Vaissière, C Sawan, Z Herceg - Mutation Research/Reviews in Mutation …, 2008 - Elsevier
… Evidence suggests that these marks are dynamically linked in the epigenetic control of
gene expression and that their deregulation plays an important role in tumourigenesis [1], [6]. …

Epigenetic control of hypertension by DNA methylation: a real possibility

PM João Job, FA dos Reis Lívero… - Current Pharmaceutical …, 2021 - ingentaconnect.com
… advances in research on DNA methylation in the development of … Studies of the involvement
of DNA methylation have greatly … recent findings of DNA methylation in hypertension, mainly …

Targeting deregulated epigenetic control in cancer

SK Zaidi, AJ Van Wijnen, JB Lian… - Journal of cellular …, 2013 - Wiley Online Library
… —especially the reversible silencing of genes—is critical for key biological processes,
targeting DNA methylation machinery inevitably results in unintended consequences, often …

Stress, epigenetic control of gene expression and memory formation

AF Trollope, M Gutièrrez-Mecinas, KR Mifsud… - Experimental …, 2012 - Elsevier
DNA methylation and its role in epigenetics Another major epigenetic process is DNA
methylation, which involves the covalent addition of a methyl group to the 5-position of the …