DNA methylation and epigenetic defects in carcinogenesis
R Holliday - … Research/Fundamental and Molecular Mechanisms of …, 1987 - Elsevier
… DNA methylation can be carcinogenic and that turnout cells are altered in DNA methylation.
… pattern of DNA methylation. Evidence that one or more steps in carcinogenesis may have an …
… pattern of DNA methylation. Evidence that one or more steps in carcinogenesis may have an …
DNA methylation and epigenetic mechanisms
R Holliday - Cell biophysics, 1989 - Springer
… The phenotypes, which at first sight appear to be a result of a mutation in a structural gene,
are in all probability a result of the epigenetic inactivation of these genes by DNA methylation. …
are in all probability a result of the epigenetic inactivation of these genes by DNA methylation. …
[PDF][PDF] DNA methylation: a form of epigenetic control of gene expression
DHK Lim, ER Maher - The Obstetrician & Gynaecologist, 2010 - dhmg.amu.edu.pl
… In addition, disordered epigenetic gene regulation is a … in epigenetic gene regulation
including DNA methylation; … reader to the concept of DNA methylation as a regulator of gene …
including DNA methylation; … reader to the concept of DNA methylation as a regulator of gene …
DNA methylation and epigenetic inheritance
R Holliday - … Transactions of the Royal Society of …, 1990 - royalsocietypublishing.org
… The general features of epigenetic … specific DNA methylation will be discussed later. Initially,
I will consider the question of the epigenetic control of gene activity by DNA methylation in …
I will consider the question of the epigenetic control of gene activity by DNA methylation in …
Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm
… pathophysiology associated with aberrant sperm DNA methylation may provide long-… erasure
of DNA methylation in primordial germ cells results in an epigenetic defect of sperm, some …
of DNA methylation in primordial germ cells results in an epigenetic defect of sperm, some …
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
EM Wolff, Y Chihara, F Pan, DJ Weisenberger… - Cancer research, 2010 - AACR
… of a field defect has been postulated. In this study, we compared the DNA methylation patterns
between noninvasive and invasive UC and the DNA methylation patterns between normal…
between noninvasive and invasive UC and the DNA methylation patterns between normal…
DNA methylation in development and human disease
S Gopalakrishnan, BO Van Emburgh… - … Molecular Mechanisms of …, 2008 - Elsevier
… insights into the epigenetic crosstalk between DNA methylation, histone modifications, and
… studies in DNA methylation primarily focusing on the interplay between different epigenetic …
… studies in DNA methylation primarily focusing on the interplay between different epigenetic …
DNA methylation and human disease
KD Robertson - Nature Reviews Genetics, 2005 - nature.com
… Loss of imprinting (LOI) is the disruption of imprinted epigenetic marks through gain or loss
of DNA methylation, or simply the loss of normal allele-specific gene expression 28 . Studies …
of DNA methylation, or simply the loss of normal allele-specific gene expression 28 . Studies …
DNA methylation in epigenetic control of gene expression
A Razin, B Kantor - Epigenetics and chromatin, 2005 - Springer
… DNA methylation is a flexible epigenetic feature of the genome that can be established,
maintained and erased. Being flexible, this feature had been successfully employed to serve the …
maintained and erased. Being flexible, this feature had been successfully employed to serve the …
Genetic and epigenetic defects in mental retardation
JM Kramer, H van Bokhoven - The international journal of biochemistry & …, 2009 - Elsevier
… More detailed knowledge about the altered DNA methylation and histone marks that are
introduced by epigenetic gene mutations as well as more insight into neuronal genes whose …
introduced by epigenetic gene mutations as well as more insight into neuronal genes whose …
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