[PDF][PDF] DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma

A Villanueva, A Portela, S Sayols, C Battiston… - …, 2015 - Wiley Online Library
… Unsupervised hierarchical clustering of 10 normal liver (yellow), 9 cirrhotic liver (orange), …
Considering that DNA methylation provides one of the layers of epigenetic control of tissue …

Germline-derived DNA methylation and early embryo epigenetic reprogramming: the selected survival of imprints

D Monk - The international journal of biochemistry & cell biology, 2015 - Elsevier
DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic … in mouse under the hierarchical influence of the …

Epigenetic reprogramming in cancer

ML Suvà, N Riggi, BE Bernstein - Science, 2013 - science.org
DNA methylation is a relatively stable epigenetic modification that mediates silencing of
repetitive elements and certain gene promoters (32). Methylationepigenetic hierarchy, with rare …

Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation

LO Dannenberg, HJ Edenberg - BMC genomics, 2006 - Springer
Background DNA methylation and histone deacetylation are epigenetic mechanisms that play
major roles in eukaryotic gene regulation. We hypothesize that many genes in the human …

Genomic DNA methylation signatures enable concurrent diagnosis and clinical genetic variant classification in neurodevelopmental syndromes

E Aref-Eshghi, DI Rodenhiser, LC Schenkel… - The American Journal of …, 2018 - cell.com
… Supporting this concept, we have previously reported DNA methylation epigenetic (epi-) …
The identified probes were examined using an unsupervised hierarchical clustering to ensure …

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Epigenetic modifications such as DNA methylation are known to influence gene expression
and thus biological function [1] and alterations in epigenetic … by the hierarchical clustering …

An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

M Walter, A Teissandier, R Pérez-Palacios, D Bourc'His - Elife, 2016 - elifesciences.org
… (E) Heatmap and hierarchical clustering of average CpG methylation over 69 transposon
families as measured by WGBS. (F) Left panel: Tukey boxplot representation of CpG …

DNA methylation contributes to natural human variation

H Heyn, S Moran, I Hernando-Herraez… - Genome …, 2013 - genome.cshlp.org
… Hence, epigenetic variations, and in particular DNA methylation, might … A) Hierarchical
clustering of 439 pop-CpG sites separating the three populations using absolute DNA methylation

Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study

BS Winsvold, P Palta, E Eising, CM Page… - …, 2018 - journals.sagepub.com
Background The biological mechanisms of headache chronification are poorly understood.
We aimed to identify changes in DNA methylation associated with the transformation from …

Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease

JI Young, SK Sivasankaran, L Wang, A Ali… - Neurology …, 2019 - AAN Enterprises
… Unsupervised hierarchical clustering of the methylome data revealed 1 outlier from the CG
DNA methylation changes in the DMV, SN, and CG supports our hypothesis of an epigenetic