… In the case of epigenetic reprogramming of the OCT4 promoter … function of DNA methylation
in epigenetic repression of a subset of genes during development, which might function …

… Moreover, the approach of EGE is uniquely suited to investigate functions of epigenetic
writers and erasers and to elucidate consequences of epigenetic marks at any given chromatin …

… Epigenetic modifiers, such as histone deacetylase (HDAC) … Moreover, the detection of
epigenetic marks in key immune … recent discoveries concerning the epigenetic regulation of the …

… Such genetic alterations have been traditionally difficult to target, … epigenetic deficiencies,
which we describe below. We also discuss an alternative approach that targets loss-of-function …

… ‘Aging epigenetics’ is an emerging field that promises exciting revelations in the near future.
Here we focus on the functional and biological significance of the epigenetic alterations that …

… target lysines for mono-, di- or tri-methylation and are shown to have diverse functions.In …
methylation, and methylation regulates distinct functions of these proteins. Among various …

… enzymes may serve as druggable targets. This chapter, which will focus on the … also function
as epigenetic marks. It is worth noting that various studies have established the 5hmC mark …

… potential therapeutic targets. The presence of multiple epigenetic aberrations within malignant
tissue and the abilities of cells to develop resistance suggest that epigenetic therapies are …

… able to directly test the causal function of individual epigenetic marks are in high demand. …
If particular gRNAs target the chromatin modifier to functional sites, phenotypic changes are …

… The best described function of the E2F transcription factors is the regulation of genes …
H3K27me3 marked polycomb target genes thereby allowing maintenance of this epigenetic mark …