… We have used imprinted genes as a model system to compare epigenetic … have a significantly
different epigenetic profile for these four marks to imprinted genes without a promoter DMR …

… Genomic imprinting refers to an epigenetic mark that … more on epigenetic mechanisms while
at the same time evading them. The alleles of imprinted genes are marked epigenetically at …

… DNA methylation is the best-established epigenetic mark that is critical for the allele-specific
expression of imprinted genes. This mark must be correctly established in the germline, …

… -wide epigenetic marks is deciphering which marks are instructive, which marks are occurring
as … of transcription or repression) and which marks are less relevant than others. Applying …

… However, the exact nature of the epigenetic mark remainsto be established. Generally, it
is accepted that imprinted genes possess acis-acting regulatory sequence that controls the …

… Great effort has recently been undertaken to catalogue the genome-wide patterns of epigenetic
marks—creating reference epigenomes—which will deepen our understanding of their …

… imprinting; they regulate gene expression in a dosage-dependent and parent-of-origin-specific
manner, respectively. Both genetic and environmental factors impact epigenetic marks, …

… In terms of epigenetic mechanisms, imprinted expression is … of imprinted genes, whereby
the position of such epigenetic … as an important epigenetic mark distinguishing maternally …

… influence gene expression and how epigenetic modifications … H19 genes are located in the
distal part of chromosome 7 with a 90-kb interval. These two genes are reciprocally imprinted …

… These CpG islands belong to imprinted genes or genes on inac tivated X chromosome.
Promotors associated with such CpG islands remain silent during the whole life of the organism. …