… further efforts to elucidate epigenetic alterations in cancer, and to subsequently develop new
epigenetic therapies. This review delineates the latest cancer epigenetic models, the recent …

… and are important for establishing DNA methylation patterns, whereas DNMT1 acts … of DNA
methylation following DNA replication. DNA methylation is a central mechanism of epigenetic …

… in DNA … DNA methylation as an epigenetic determinant of tumorigenesis, focusing on (i)
the distribution and maintenance of DNA methylation in normal cells (ii) DNA methylation-…

… Epigenetic therapy scope is likely to increase in future. … In epigenetic modifications
DNA methylation is most widely studied in mammals. In promoter gene CPG dinucleotide is …

… genetics and epigenetics in cancer can be bidirectional 1 . In terms of DNA methylation,
tumours frequently show a global loss of DNA methylation 3 with gains of focal DNA methylation …

… the cancer cell specificity of the combination of DNA methylation and H3K27me3. Then, to …
-specific epigenetic therapy, we will show whether or not a combination of DNA demethylation …

… Epigenetic therapy based on DNA methylation inhibitors … a therapeutic regimen to patients
with DNA hypermethylation-… transfer a methyl group to genomic DNA, how they function in …

… in histones can influence DNA methylation, then it is possible that the methylation of genes
… mechanisms of epigenetic regulation (DNA methylation, histone methylation and acetylation, …

… patterns can also be used to develop and refine epigenetic therapies for cancer. In clinical
trials of demethylating agents, changes in patients' DNA methylation patterns should be …

… of serum- or stool-derived methylated DNA as population-based screening … DNA methylation,
describes a better use of prevailing technologies that discover novel DNA methylation …