… target two major epigenetic systems. Those drugs that inhibit DNA methylation and those
drugs that inhibit histone deacetylation ( Table 1 ). Epigenetic therapies have demonstrated …

… Abstract: DNA methylation is an epigenetic modification involved in gene expression
regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

… therapies. In this review, we will focus on recent advances in epigenetic therapy in leukemia.
… These results also indicated that DNA methylation was the dominant alteration and DNA …

… Epigenetic therapies using the inhibitors of these … on DNA methylation inhibitors and histone
deacetylation inhibitors evaluating their potential for future application in epigenetic therapy. …

… Epigenetic events, such as aberrant DNA methylation, have been demonstrated to silence …
interesting target for intervention with specific inhibitors of DNA methylation, such as 5-aza-2′…

… Driven by complex layers that include aberrant DNA methylation and histone modification,
epigenetic aberrations have emerged as critical processes that disrupt cellular machinery and …

… This review describes the role that epigenetic changes play in the pathogenesis of cancer, …
of epigenetic therapeutic agents in laboratory studies and clinical trials. DNA methylation is …

… So far, epigenetic therapies, including HDAC inhibitors and … of solid tumours with epigenetic
therapies and discuss … most widely studied epigenetic changes is DNA methylation, …

… Abstract: Epigenetic factors such as DNA methylation and histone deacetylation are known
to contribute to the malignant transformation of cells by silencing critical genes. Drugs that …

… DNA methylation is a chemically reversible epigenetic modification that regulates the
chromatin structure and gene expression, and thereby takes part in various cellular processes like …