… cell specificity of the combination of DNA methylation and H3K27me3. Then, to reveal the …
-specific epigenetic therapy, we will show whether or not a combination of DNA demethylation …

… further efforts to elucidate epigenetic alterations in cancer, and to subsequently develop new
epigenetic therapies. This review delineates the latest cancer epigenetic models, the recent …

… in gene regulation and therefore influence our understanding of how this epigenetic mechanism
… genome-wide profiles of H3K27me3, gene expression and DNA methylation in severely …

… baseline DNA methylation of genes affected by epigenetic therapy, we used methylation
values … (>50% promoter DNA methylation with no H3K9me2 or H3K27me3), both histone and …

… removal of one mark, such as DNA methylation, may lead to the rapid accumulation of an
alternative silencing mark such as H3K27me3 catalysed by EZH2. This process, termed an ‘…

… PcG acquire DNA methylation to some extent. In this case, H3K27me3 and DNA methylation
co-… , the promise for epigenetic therapies as an essential treatment option will be achieved. …

… a target for epigenetic therapy. Analysis of DNA methylation and H3K27me3 expression levels
in … cell lines revealed that ~1/4 of DNA methylated genes underwent DNA methylation and …

… implantation embryos and how these epigenetic distinctions contribute to the regionalized
… on two major epigenetic silencing mechanisms, H3K27me3 and DNA methylation (DNAme), …

… in mitosis; 4) PRC2 binds directly to the H3K27me3 mark; 5) maintenance of PRC2-…
H3K27me3 methylation, we suggest a model for the mechanism by which the H3K27 methylation …

… Epigenetics includes changes such as DNA methylation, microRNA and histone
modifications, which together make up the epigenome [1]. Here we focused on the histone …