Small-sized extracellular vesicles (EVs) derived from acute myeloid leukemia bone marrow mesenchymal stem cells transfer miR-26a-5p to promote acute myeloid …

D Ji, Y He, W Lu, Y Rong, F Li, X Huang, R Huang… - Human Cell, 2021 - Springer
… cells (BMSCs) in acute myeloid leukemia (AML) microenvironment undergo modification
that includes expression of contents in the small-sized extracellular vesicles (EVs) they secrete. …

… myeloid leukemia cells functionally compromise hematopoietic stem/progenitor cells inhibiting normal hematopoiesis through the release of extracellular vesicles

S Trino, I Laurenzana, D Lamorte, G Calice… - Frontiers in …, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal disorder of
hematopoietic stem/progenitor cells (HSPCs). It is not well known how leukemia cells alter …

Treatment failure in acute myeloid leukemia: focus on the role of extracellular vesicles

R Mirfakhraie, L Noorazar, M Mohammadian… - Leukemia Research, 2022 - Elsevier
Acute myeloblastic leukemia (AML) is one of the most … have looked at the role of extracellular
vesicles (EVs) secreted by … AML treatment by looking at the role of extracellular vesicles. …

Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo

C Bouvy, A Wannez, J Laloy, C Chatelain, JM Dogné - Leukemia research, 2017 - Elsevier
extracellular vesicles (EVs) has been suggested. The aim of this research was to investigate
the role of EVs in chemo-resistance in acute myeloid … biomarkers in acute myeloid leukemia. …

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

M Mendes, AC Monteiro, E Neto, CC Barrias… - International Journal of …, 2024 - mdpi.com
Acute myeloid leukaemia (AML) management remains a significant challenge in oncology …
of AML progression, highlighting the pivotal role of extracellular vesicles (EVs) in the dynamic …

Effect of acute myeloid leukemia-derived extracellular vesicles on bone marrow mesenchymal stromal cells: expression of poor prognosis genes

Y Kargar-Sichani, MH Mohammadi, V Amiri… - Archives of medical …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder resulting from a complex
… In this context, extracellular vesicles (EVs) have been shown to play an essential role in …

A proteomic approach to understand the clinical significance of acute myeloid Leukemia–Derived extracellular vesicles reflecting essential characteristics of leukemia

KW Kang, H Kim, W Hur, J Jung, SJ Jeong… - Molecular & Cellular …, 2021 - ASBMB
Extracellular vesicle (EV) proteins from acute myeloid leukemia (AML) cell lines were
analyzed using mass spectrometry. The analyses identified 2450 proteins, including 461 …

[HTML][HTML] Uncovering the expression of circPVT1 in the extracellular vesicles of acute myeloid leukemia patients

M Ghetti, I Vannini, MT Bochicchio, I Azzali… - Biomedicine & …, 2023 - Elsevier
… several cancer types and immunosuppressive properties in myeloid and lymphoid cell
subsets. In this study, we characterized EVs from acute myeloid leukemia (AML) patients in terms …

Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukaemia

CS Hong, E Jeong, M Boyiadzis… - … of Extracellular Vesicles, 2020 - Taylor & Francis
… Most patients with acute myeloid leukaemia (AML) experience disease recurrence after
chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (…

Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway

C Zhao, Y Zhao, J Zhao, G Meng, S Huang, Y Liu… - Cancer Gene …, 2022 - nature.com
… microRNAs (miRNAs or miRs) can be delivered from acute myeloid leukemia (AML) cells to
hematopoietic stem cells (HSCs) to regulate hematopoietic function via extracellular vesicles